fMRI of Vulnerable Brain Regions in Persons at Risk for Alzheimer's Disease
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Alzheimer Disease, Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 40 - 85 |
| Updated: | 4/21/2016 |
| Start Date: | January 2003 |
| End Date: | July 2016 |
The purpose of this study is to investigate the organization of memory and develop future
methods for early detection of AD. Using functional magnetic resonance imaging (fMRI), we
examine the responsiveness of the brain to memory tasks, specifically focusing on regions of
the brain (the mesial temporal lobe and posterior cingulate) that are known to be involved
in early stages of Alzheimer's disease (AD). Of interest are differences in brain activation
between people with and without a family history of AD and other risk factors.
methods for early detection of AD. Using functional magnetic resonance imaging (fMRI), we
examine the responsiveness of the brain to memory tasks, specifically focusing on regions of
the brain (the mesial temporal lobe and posterior cingulate) that are known to be involved
in early stages of Alzheimer's disease (AD). Of interest are differences in brain activation
between people with and without a family history of AD and other risk factors.
Inclusion Criteria:
- MCI Group: Diagnosis of mild cognitive impairment
- AD Family History Group: Confirmed family history of Alzheimer's and concurrent
enrollment in the Wisconsin Registry for Alzheimer's Prevention (WRAP)
- Control Groups: Cognitively healthy and both parents survived past age 70 with no
memory problems
Exclusion Criteria:
- Claustrophobia
- Metallic or electronic implants or devices that are not MRI-safe
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