Study to Assess the Efficacy and Safety of a PARP Inhibitor for the Treatment of BRCA-positive Advanced Breast Cancer
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Breast Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - 127 |
| Updated: | 2/28/2019 |
| Start Date: | June 15, 2007 |
| End Date: | December 31, 2019 |
A Phase II Open-label, Non-comparative, International, Multicentre Study to Assess the Efficacy and Safety of KU 0059436 (Olaparib) Given Orally Twice Daily in Patients With Advanced BRCA1 or BRCA2 Associated Breast Cancer
The purpose of the study is to see if the drug KU 0059436 (olaparib) is effective and well
tolerated in treating patients with measurable BRCA1- or BRCA2-positive advanced breast
cancer and for whom no curative therapeutic option exists.
tolerated in treating patients with measurable BRCA1- or BRCA2-positive advanced breast
cancer and for whom no curative therapeutic option exists.
Inclusion Criteria:
- Advanced breast cancer with positive BRCA1 or BRCA2 status
- Failed at least one prior chemotherapy
- In investigators opinion, no curative standard therapy exists
- Measurable disease
Exclusion Criteria:
- Brain metastases
- Less than 28 days since last treatment used to treat the disease
- Considered a poor medical risk due to a serious uncontrolled disorder
We found this trial at
6
sites
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