Fibrin Melanoma Axillary Node Study in Patients With Melanoma
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Skin Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/5/2018 |
| Start Date: | May 2002 |
| End Date: | May 2019 |
A Randomized Trial Evaluating the Use of Fibrin Tissue Adhesive Following Axillary Node Dissection in Patients With Melanoma
Primary Objective:
- To determine whether the use of a fibrin sealant applied to axillary soft tissues
following node dissection can result in earlier drain removal.
Secondary Objectives:
- To determine the postoperative morbidity rate using fibrin sealant following axillary
node dissection.
- To assess patient-valuation of outcome by performing a cost-benefit analysis using a
willingness-to-pay model.
- To determine if serum levels, lymphatic fluids level, or cutaneous expression of
vascular endothelial growth factor-D (VEGF-D), vascular endothelial growth factor-C
(VEGF-C) or their receptor, vascular endothelial growth factor receptor-3 (VEGFR-3)
correlates with nodal tumor burden or development of lymphedema in patients with
melanoma.
- To determine whether the use of a fibrin sealant applied to axillary soft tissues
following node dissection can result in earlier drain removal.
Secondary Objectives:
- To determine the postoperative morbidity rate using fibrin sealant following axillary
node dissection.
- To assess patient-valuation of outcome by performing a cost-benefit analysis using a
willingness-to-pay model.
- To determine if serum levels, lymphatic fluids level, or cutaneous expression of
vascular endothelial growth factor-D (VEGF-D), vascular endothelial growth factor-C
(VEGF-C) or their receptor, vascular endothelial growth factor receptor-3 (VEGFR-3)
correlates with nodal tumor burden or development of lymphedema in patients with
melanoma.
Patients in this study are scheduled to have axillary node dissection as part of their
surgery for treatment of their melanoma.
Within 2 weeks before entry into the study, patients will have a complete physical exam and
medical history.
These patients will be randomly assigned (as in the toss of a coin) to one of two groups.
Patients in one group will receive TISSEEL applied externally to the dissected axillary area.
Patients in the other group will receive no fibrin sealant.
For patients who are admitted to the hospital, the surgical site will be monitored by the
surgeon for evidence of wound complications in the first 24 hours after surgery. At the time
of discharge from the hospital, patients will be instructed in drain care and how to measure
the drainage each day until the drain is removed.
The contents of the drain will be collected from patients during the first day after surgery,
during the first return follow-up visit to M.D. Anderson Cancer Center, and during drain
removal (unless these latter 2 dates are the same).
Follow-up wound exams will be performed by the local primary physician or in the M.D.
Anderson Melanoma Clinic between 1-4 weeks and 6 weeks after surgery. Participation will be
over at the 6-week follow-up.
THIS IS AN INVESTIGATIONAL STUDY. The sealant is FDA approved, though its use in this study
is experimental. About 115 patients will take part in this study. All will be enrolled at M.
D. Anderson.
surgery for treatment of their melanoma.
Within 2 weeks before entry into the study, patients will have a complete physical exam and
medical history.
These patients will be randomly assigned (as in the toss of a coin) to one of two groups.
Patients in one group will receive TISSEEL applied externally to the dissected axillary area.
Patients in the other group will receive no fibrin sealant.
For patients who are admitted to the hospital, the surgical site will be monitored by the
surgeon for evidence of wound complications in the first 24 hours after surgery. At the time
of discharge from the hospital, patients will be instructed in drain care and how to measure
the drainage each day until the drain is removed.
The contents of the drain will be collected from patients during the first day after surgery,
during the first return follow-up visit to M.D. Anderson Cancer Center, and during drain
removal (unless these latter 2 dates are the same).
Follow-up wound exams will be performed by the local primary physician or in the M.D.
Anderson Melanoma Clinic between 1-4 weeks and 6 weeks after surgery. Participation will be
over at the 6-week follow-up.
THIS IS AN INVESTIGATIONAL STUDY. The sealant is FDA approved, though its use in this study
is experimental. About 115 patients will take part in this study. All will be enrolled at M.
D. Anderson.
Inclusion Criteria:
1. Part I - Inclusion Criteria, patients that consent to participate.
2. Patients with melanoma who have undergone axillary dissection within the last six
months as part of their surgical treatment will be considered for the study.
Exclusion Criteria:
1. Part II - Exclusion Criteria, patients with known hypersensitivity to bovine proteins.
2. Patient has undergone prior radiation therapy to the operative site.
3. Patient is pregnant or lactating.
4. Patient is steroid dependent within prior 6 months.
5. Patient has used aspirin or other anti-platelet drug (excluding Celebrex) within seven
days of operation.
6. Patient has pre-existing lymphedema.
7. Patient has other pre-existing medical conditions with evidence of organ dysfunction
as determined by principal investigator.
We found this trial at
1
site
1515 Holcombe Blvd
Houston, Texas 77030
Houston, Texas 77030
713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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