DNA Array Analysis of Patients With Cervical Cancer
| Status: | Completed |
|---|---|
| Conditions: | Cervical Cancer, Cervical Cancer, Cancer, Women's Studies |
| Therapuetic Areas: | Oncology, Reproductive |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 12/2/2017 |
| Start Date: | June 20, 2000 |
| End Date: | November 20, 2017 |
A Pilot Study of Early Changes in DNA Array Expression Following Chemo-Radiation Treatment of Cervical Cancer
The goal of this clinical research study is to find out if the expression of certain genes is
linked with the response of cervical cancer to radiation. Researchers will study a large
number of genes located in tumor material to learn this information.
linked with the response of cervical cancer to radiation. Researchers will study a large
number of genes located in tumor material to learn this information.
Patients in this study are already scheduled to begin radiation therapy. Researchers will get
tumor cells by taking two biopsies of the cervix. The first biopsy of the cervical tumor will
be done before any treatment is given. The second biopsy will be performed about 48 hours
after the radiation treatment has begun. They will then study the cells in the lab with a new
technique for studying gene expression called DNA array, as well as human papillomavirus
(HPV) analysis, quantification of apoptosis levels, hematoxylin and eosin staining, and
storage of tissue for future research.
The patterns of gene expression in the biopsies will be compared with the success of
radiation treatments.
Some of the material will also be stored and used in the future for other research projects.
This is an investigational study. A total of 18 patients will take part in this study. All
will be enrolled at UTMDACC.
tumor cells by taking two biopsies of the cervix. The first biopsy of the cervical tumor will
be done before any treatment is given. The second biopsy will be performed about 48 hours
after the radiation treatment has begun. They will then study the cells in the lab with a new
technique for studying gene expression called DNA array, as well as human papillomavirus
(HPV) analysis, quantification of apoptosis levels, hematoxylin and eosin staining, and
storage of tissue for future research.
The patterns of gene expression in the biopsies will be compared with the success of
radiation treatments.
Some of the material will also be stored and used in the future for other research projects.
This is an investigational study. A total of 18 patients will take part in this study. All
will be enrolled at UTMDACC.
Inclusion Criteria:
1. Newly diagnosed cervical cancer: clinical Stage IB -IIIB
2. Invasive pure squamous cell carcinoma
3. Planned treatment with concurrent cisplatinum/5-fluorouracil chemotherapy and pelvic
radiation
Exclusion Criteria:
1. Previous cervical cancer treatment including but not limited to transvaginal cone
irradiation
We found this trial at
1
site
1515 Holcombe Blvd
Houston, Texas 77030
Houston, Texas 77030
713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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