Compare Bosutinib To Imatinib In Subjects With Newly Diagnosed Chronic Phase Philadelphia Chromosome Positive CML



Status:Completed
Conditions:Other Indications, Blood Cancer
Therapuetic Areas:Oncology, Other
Healthy:No
Age Range:18 - Any
Updated:1/10/2019
Start Date:February 5, 2008
End Date:May 27, 2015

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A PHASE 3 RANDOMIZED, OPEN-LABEL STUDY OF BOSUTINIB VERSUS IMATINIB IN SUBJECTS WITH NEWLY DIAGNOSED CHRONIC PHASE PHILADELPHIA CHROMOSOME POSITIVE CHRONIC MYELOGENOUS LEUKEMIA

Two-arm, randomized, open-label trial designed to evaluate the efficacy and safety of
bosutinib alone compared to imatinib alone in subjects newly diagnosed with chronic phase
Chronic Myelogenous Leukemia (CML). The primary endpoint is cytogenetic response rate at one
year.


Inclusion Criteria:

- Cytogenetic diagnosis of chronic phase Ph+ CML diagnosed less than 6 months.

- Diagnosis of CML chronic phase confirmed.

- Adequate hepatic and renal function.

- Able to take oral tablets.

Exclusion Criteria:

- Exclusions include Philadelphia negative CML.

- Prior anti-leukemia treatment.

- Prior stem cell transplant.
We found this trial at
33
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300 Pasteur Drive
Stanford, California 94304
1329
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5347 Main St # 203
New Port Richey, Florida 34652
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24 Sturtevant St
Orlando, Florida 32806
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Anaheim, California 92801
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Atlanta, Georgia 30341
801
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Atlanta, GA
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6410 Rockledge Dr #660
Bethesda, Maryland 20817
(301) 571-0019
Center for Cancer & Blood Disorders Widely recognized for its compassionate, expert care, the Center...
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Bethesda, MD
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Beverly Hills, California 90211
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Brownstown, Michigan 48183
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Chattanooga, Tennessee 37404
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Cherry Hill, New Jersey
1232
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Cherry Hill, NJ
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Cherry Hill, New Jersey 08003
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Dearborn, Michigan 48126
835
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Dearborn, MI
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2799 W Grand Blvd
Detroit, Michigan 48202
(313) 916-2600
Henry Ford Hospital Founded in 1915 by auto pioneer Henry Ford and now one of...
841
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Detroit, MI
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Detroit, Michigan 48322
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Farmington, New Mexico 87401
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Farmington, NM
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Fountain Valley, California 92708
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Fountain Valley, CA
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Hazard, Kentucky 41701
801
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Hazard, KY
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1515 Holcombe Blvd
Houston, Texas 77030
 713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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Houston, TX
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Hudson, Florida 34667
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Hudson, FL
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643
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Indianapolis, IN
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646
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La Jolla, California 92093
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La Jolla, California
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La Jolla, CA
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La Plata, Buenos Aires
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La Plata,
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New Port Richey, Florida 34652
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Salinas, Kansas 67401
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Salinas, KS
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San Diego, California 92103
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230 Nebraska St.
Sioux City, Iowa 51101
712-252-0088
Siouxland Hematology-Oncology Associates, LLP Siouxland Hematology-Oncology Associates (SHOA) provides medical oncology treatment. In addition to...
336
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Sioux City, IA
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Somerville, New Jersey 08876
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Somerville, NJ
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Stanford, California 94305
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Stanford, CA
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300 Pasteur Dr
Stanford, California 94305
(650) 723-4000
Stanford Univ Med Ctr The Medical Center is uniquely advantaged by its location on the...
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Stanford, CA
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Tarpon Springs, Florida 34689
1094
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Tarpon Springs, FL
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818 N. Emporia, #403
Wichita, Kansas 67214
(316) 262-4467
Cancer Center of Kansas The physicians of Cancer Center are hematologists and oncologists. The staff...
27
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Wichita, KS
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