A Pilot Study of Switching From One Pain Medication to Another (Opioid Rotation)
| Status: | Completed |
|---|---|
| Conditions: | Chronic Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | November 2007 |
| End Date: | August 2008 |
A Pilot Study of Rapid Opioid Rotation and Titration of Oxymorphone
The purpose of this study is to see if changing from one pain medication like morphine or
oxycodone to another pain medication, oxymorphone (OPANA®), will be helpful to patients.
This study will examine if the switching from one pain medication to another can be done
over a 24 hour period. Oxymorphone, the drug being studied, is an FDA approved drug for
treatment of severe pain.
oxycodone to another pain medication, oxymorphone (OPANA®), will be helpful to patients.
This study will examine if the switching from one pain medication to another can be done
over a 24 hour period. Oxymorphone, the drug being studied, is an FDA approved drug for
treatment of severe pain.
Inclusion Criteria:
- Age of 18 to no upper limit
- Chronic pain of nociceptive, neuropathic, or mixed origin
- Patients with chronic non cancer pain
- Ongoing chronic opioid treatment with either oral morphine or oxycodone (long term -
more than 3 months of at least a total daily opioid dose of 60 mg morphine or of 30
mg oxycodone)
- Pain of moderate intensity (>4, on the numerical scale 0-10) despite ongoing opioid
therapy>
- Non-pregnant, non-lactating women
- Sufficient language skills to communicate with research staff
Exclusion Criteria:Non-ambulatory patients
- Clinically significant respiratory, renal, hepatic, or cardiac disease.
- Documented diagnosis of sleep apnea (the study physician may exclude patients who
present with clinical features and complaints suggestive of a diagnosis of probable
sleep apnea)
- History of illicit drug or alcohol dependence or abuse, abnormal drug taking /
seeking behaviors
- Severe depression (> 26 on the BDI)
- Patients who exhibit a score on the Mini Mental Status Exam (MMSE) of 26 or less.
(The range of scores for mild dementia is 21-26 on the MMSE).
- Workman compensation, current or pending medical-legal litigation
- Hypersensitivity to study medication (oxymorphone)
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