A Timeline Study of Alcohol Use and Its Relationship to Insomnia

Inclusion Criteria:

- Subjects must be between the ages of 18-70, may be male or female, and from any
ethnic background.

- Individuals must have the capacity to give IRB-approved study consent.

- Subjects must at least have a lifetime history of being heavy alcohol drinkers (i.e.,
drinks approximately 21 alcoholic drinks or more per week). Alternatively, subjects
are eligible if they meet criteria for a lifetime history of either alcohol
dependence or alcohol abuse. Overall, a subject must meet at least one of these
alcohol criteria: a lifetime history of heavy drinking, alcohol abuse or alcohol
dependence.

- Subjects must have a complaint of chronic insomnia, reporting either six or less
hours TST, on average at least three times per week.

Exclusion Criteria

- Potential subjects with a lifetime diagnosis of Bipolar Affective Disorder,
Schizophrenia, Borderline Personality Disorder, dementia of any type, or epilepsy
will not be admitted to the study.

- Subjects will be excluded with a diagnosis of any other substance dependence syndrome
other than alcohol dependence, nicotine dependence, and/or caffeine dependence.
However, individuals may have a history of episodic abuse of cannabis, cocaine,
sedatives/hypnotics and opiates, amphetamines, and hallucinogens. Also, subjects may
be on prescription benzodiazepine or related sedative/hypnotic therapy.

- Any condition or treatment of a condition that is likely to confound the experimental
design or the results will be prohibited by the PI.