Optical Clearing of the Skin in Conjunction With Laser Treatments
| Status: | Completed |
|---|---|
| Conditions: | Acne, Acne, Cosmetic |
| Therapuetic Areas: | Dermatology / Plastic Surgery |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | March 2004 |
| End Date: | July 2008 |
The research hypothesis is that topical application of a mixture of pre-polymers of
polypropylene glycol and polyethylene glycol (an optical clearing agent) will reduce skin
light scattering, increasing the amount of light reaching the target for diagnostic as well
as therapeutic purposes.
polypropylene glycol and polyethylene glycol (an optical clearing agent) will reduce skin
light scattering, increasing the amount of light reaching the target for diagnostic as well
as therapeutic purposes.
The researchers expect that application of the optical clearing agent for treatment of
benign vascular lesions, tattoos, nevus of Ota, hypertrichosis, scars, acne and sebaceous
hyperplasia will result in
1. decreased reflectance of the predominant color from the surface of skin (decreased red
light scattering in case of benign vascular lesions, etc) as compared to the control
group.
2. greater Optical Coherence Tomography a non-invasive light based imaging method imaging
depth as compared to the control group.
3. greater improvement in the treatment outcome (decrease in the erythema index following
laser treatment of vascular lesions as compared to the laser alone group; improved
lightening of the tattoo or nevus of Ota as compared to the laser treatment alone
group; significant decrease in hair re-growth as compared to laser treatment alone in
patients seeking hair removal; greater improvement of scars, acne and sebaceous
hyperplasia).
benign vascular lesions, tattoos, nevus of Ota, hypertrichosis, scars, acne and sebaceous
hyperplasia will result in
1. decreased reflectance of the predominant color from the surface of skin (decreased red
light scattering in case of benign vascular lesions, etc) as compared to the control
group.
2. greater Optical Coherence Tomography a non-invasive light based imaging method imaging
depth as compared to the control group.
3. greater improvement in the treatment outcome (decrease in the erythema index following
laser treatment of vascular lesions as compared to the laser alone group; improved
lightening of the tattoo or nevus of Ota as compared to the laser treatment alone
group; significant decrease in hair re-growth as compared to laser treatment alone in
patients seeking hair removal; greater improvement of scars, acne and sebaceous
hyperplasia).
Inclusion Criteria:
- Adult 18 years and older
- Lesion diagnoses in an area measuring 3 cm2 or more on any body site
- Apparent good health
Exclusion Criteria:
- Pregnant women
- History of cutaneous photosensitivity
- History of photodermatoses
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