Use of Diffuse Optical Spectroscopy for Evaluation of the Trauma/Critically Care Patients
| Status: | Completed |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | March 2007 |
| End Date: | April 2011 |
Trauma remains the leading cause of death and disability for Americans age 1-44. Trauma can
cause internal bleeding, and this bleeding is often hard to detect without sophisticate
tests that take time to complete and analyze.
In addition, internal bleeding, including bleeding into the lung and chest cavity, as well
as other blood loss, happens in many critically ill patients. For example, for hemorrhage,
it is very difficult to detect active hemorrhage and to determine optimal rates of fluid and
blood resuscitation.
Diffuse optical spectroscopy has the potential to accurately assess adequacy of tissue
perfusion, oxygenation, tissue oxygen extraction, and cytochrome oxidation states that may
be critical to optimal treatment, end- organ preservation, and survival.
cause internal bleeding, and this bleeding is often hard to detect without sophisticate
tests that take time to complete and analyze.
In addition, internal bleeding, including bleeding into the lung and chest cavity, as well
as other blood loss, happens in many critically ill patients. For example, for hemorrhage,
it is very difficult to detect active hemorrhage and to determine optimal rates of fluid and
blood resuscitation.
Diffuse optical spectroscopy has the potential to accurately assess adequacy of tissue
perfusion, oxygenation, tissue oxygen extraction, and cytochrome oxidation states that may
be critical to optimal treatment, end- organ preservation, and survival.
The research' want to monitor tissue perfusion and indicators of tissue damage and viability
in critically ill patients by using DOS.
Non-invasive Optical Techniques DOS,near-infrared diffuse optical spectroscopy (NIR-DOS.
NIR-DOS provides functional physiologic tissue/organ information without ionizing radiation
and without withdrawing any blood, in a cost-effective and rapid manner. The application of
frequency-domain photon migration analysis (FDPM) to NIRS allows independent measurements of
tissue absorption and scattering properties at depths of 1 cm or more below the skin
surface.
Such capabilities will improve early diagnosis, detection, optimization of therapy,
assessment of adequacy of resuscitation, and alteration in management plans for all of these
critical conditions.
in critically ill patients by using DOS.
Non-invasive Optical Techniques DOS,near-infrared diffuse optical spectroscopy (NIR-DOS.
NIR-DOS provides functional physiologic tissue/organ information without ionizing radiation
and without withdrawing any blood, in a cost-effective and rapid manner. The application of
frequency-domain photon migration analysis (FDPM) to NIRS allows independent measurements of
tissue absorption and scattering properties at depths of 1 cm or more below the skin
surface.
Such capabilities will improve early diagnosis, detection, optimization of therapy,
assessment of adequacy of resuscitation, and alteration in management plans for all of these
critical conditions.
Inclusion Criteria:
- Adult age 18 years or older, male or female
- Trauma/Critical Care patient
Exclusion Criteria:
- Subject is not Trauma/Critical Care patient
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