The Effects of Celecoxib on Bone Ingrowth
| Status: | Terminated |
|---|---|
| Conditions: | Chronic Pain |
| Therapuetic Areas: | Musculoskeletal |
| Healthy: | No |
| Age Range: | 18 - 95 |
| Updated: | 4/21/2016 |
| Start Date: | June 2008 |
| End Date: | September 2008 |
The Effects of Celecoxib on Bone Ingrowth in Porous Coated Titanium Ceramic Implants in Humans
The purpose of this study is to evaluate the effect of Celebrex on bone growth into porous
coated implants, following postoperative total knee arthroplasty administration of Celebrex
for pain relief.
coated implants, following postoperative total knee arthroplasty administration of Celebrex
for pain relief.
Inclusion Criteria:
- Male VA bilateral TKA patients 18 years or older with primary OA diagnosis
Exclusion Criteria:
- Patients with osteoporosis, hypersensitivity to Celebrex, allergy to tetracycline,
Sulfonamides, patient with asthma, urticaria, or allergic-type reactions to aspirin
or NSAIDs.
- Patients who have had CABG.
- Patients with a history of peptic ulcer disease, duodenal ulcers.
- Female patients and patients diagnosed with unstable hypertension or hypotensive,
with serum creative levels above 1.8-2.0 or diagnosed with severe renal disease.
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