Neoadjuvant ABI-007, Carboplatin and Gemcitabine in Locally Advanced Bladder Cancer
| Status: | Completed |
|---|---|
| Conditions: | Cancer, Cancer, Bladder Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | December 2007 |
| End Date: | April 2013 |
A Phase Two Trial of Neoadjuvant ABI-007, Carboplatin and Gemcitabine in Patients With Locally Advanced Carcinoma of the Bladder
Study participants will have been diagnosed with bladder cancer that has invaded the muscle
wall of the bladder. Surgery is used to remove cancer when it is in the muscle of the
bladder. Unfortunately, approximately 50% of people may have their cancer return in another
location. For this reason, researchers are focusing on new chemotherapy regimens to be given
before surgery (to remove the bladder) that may decrease the likelihood of cancer spreading.
Paclitaxel, carboplatin and gemcitabine are chemotherapy drugs known to destroy bladder
cancer cells.
ABI-007 (brand name Abraxane™) is a form of the chemotherapy drug called paclitaxel.
Standard paclitaxel is formulated with ethanol and a substance called Cremophor EL
(polyoxyethylated castor oil). However, these additives are felt to contribute to the side
effects (possibly severe) associated with paclitaxel. ABI-007 does not contain these
additives and may deliver more drug to tumor cells. ABI-007 is approved by the United States
Food and Drug Administration (FDA) in the treatment of metastatic (advanced) breast cancer,
and is being evaluated in other cancers in research studies.
This study will evaluate the safety and efficacy of the combination of ABI-007, carboplatin
and gemcitabine in the treatment of bladder cancer prior to surgery to remove the bladder.
wall of the bladder. Surgery is used to remove cancer when it is in the muscle of the
bladder. Unfortunately, approximately 50% of people may have their cancer return in another
location. For this reason, researchers are focusing on new chemotherapy regimens to be given
before surgery (to remove the bladder) that may decrease the likelihood of cancer spreading.
Paclitaxel, carboplatin and gemcitabine are chemotherapy drugs known to destroy bladder
cancer cells.
ABI-007 (brand name Abraxane™) is a form of the chemotherapy drug called paclitaxel.
Standard paclitaxel is formulated with ethanol and a substance called Cremophor EL
(polyoxyethylated castor oil). However, these additives are felt to contribute to the side
effects (possibly severe) associated with paclitaxel. ABI-007 does not contain these
additives and may deliver more drug to tumor cells. ABI-007 is approved by the United States
Food and Drug Administration (FDA) in the treatment of metastatic (advanced) breast cancer,
and is being evaluated in other cancers in research studies.
This study will evaluate the safety and efficacy of the combination of ABI-007, carboplatin
and gemcitabine in the treatment of bladder cancer prior to surgery to remove the bladder.
Inclusion Criteria:
- Histologically proven locally advanced (T2-4,N0,M0 or Tany,N1-3,M0) urothelial
carcinoma of the bladder and be candidates for cystectomy following chemotherapy.
Tumor specimens must be available for assay of molecular markers (correlative
research).
- Performance status of 0, 1 or 2 by Eastern Cooperative Oncology Group (ECOG)
criteria.
- Serum creatinine <2.0 mg/dl and/or creatinine clearance >40 ml/min.
- Granulocyte count > 1,500/mm3, platelet > 100,000/mm3, and hemoglobin > 9.0 g/dl.
- Adequate liver functions: AST and ALT < 2.5 X upper limit of normal, alkaline
phosphatase < 2.5 X upper limit of normal, and bilirubin < 1.5 mg/dl.
- Pre-existing peripheral neuropathy > grade 2
- Recovered from any effects of surgery.
- Women/men of reproductive potential may not participate unless they have agreed to
use an effective contraceptive method. Women with reproductive potential must have a
negative pregnancy test.
Exclusion Criteria:
- Prior systemic or intra-arterial chemotherapy and rior radiotherapy. (intravesical
chemotherapy allowed.)
- Pre-existing peripheral neuropathy > grade 2
- Prior malignancy [except for adequately treated basal cell (or squamous cell) skin
cancer, in situ cervical cancer or other cancer for which the patient has been
disease free for 2 years]
- Unresolved bacterial infection requiring active treatment with antibiotics.
(Treatment may begin at the conclusion of antibiotic therapy.)
- Pregnant or lactating women may not participate.
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