Age and Endothelial Progenitor Cell Mobilization
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 2/9/2019 |
| Start Date: | July 2006 |
| End Date: | December 2019 |
"The Effects of Age on Endothelial Progenitor Cell Mobilization in Humans"
This study will help to permit the development of preventative strategies as well as
cell-cased therapy for existent disease. It is hypothesized that aging is associated with
reduced vascular injury-induced endothelial progenitor cell activity, resulting in impaired
vascular repair and increased vascular disease. Patients with stable coronary artery disease
and a control group of patients undergoing coronary angiography without angioplasty will be
recruited.
cell-cased therapy for existent disease. It is hypothesized that aging is associated with
reduced vascular injury-induced endothelial progenitor cell activity, resulting in impaired
vascular repair and increased vascular disease. Patients with stable coronary artery disease
and a control group of patients undergoing coronary angiography without angioplasty will be
recruited.
Coronary artery disease is a leading cause of morbidity and mortality in our society. It is
initiated by the dysfunction of the lining of coronary arteries. There are several repair
mechanisms that are now thought to involve circulating endothelial progenitor cells that are
mobilized from the bone marrow and home to sites of endothelial injury. We hypothesize that
aging is associated with reduced vascular injury induced endothelial progenitor cell
activity, resulting in impaired vascular repair and increased coronary heart disease events.
96 patients with stable coronary artery disease will be enrolled in this study. They will
undergo either angiography alone or angiography and angioplasty. Their venous blood will be
collected immediately prior to the procedure and 20-24 hours after their procedure. The
number of endothelial progenitor cells will be assessed based on their ability to form
colonies and also to migrate under the influence of certain growth factors. These values will
be compared between both samples. All the patients will also be contacted at 6 months, 2 and
5 years after their participation in the study and the clinical outcomes of their coronary
artery disease will be correlated with the number of those aforementioned cells.
initiated by the dysfunction of the lining of coronary arteries. There are several repair
mechanisms that are now thought to involve circulating endothelial progenitor cells that are
mobilized from the bone marrow and home to sites of endothelial injury. We hypothesize that
aging is associated with reduced vascular injury induced endothelial progenitor cell
activity, resulting in impaired vascular repair and increased coronary heart disease events.
96 patients with stable coronary artery disease will be enrolled in this study. They will
undergo either angiography alone or angiography and angioplasty. Their venous blood will be
collected immediately prior to the procedure and 20-24 hours after their procedure. The
number of endothelial progenitor cells will be assessed based on their ability to form
colonies and also to migrate under the influence of certain growth factors. These values will
be compared between both samples. All the patients will also be contacted at 6 months, 2 and
5 years after their participation in the study and the clinical outcomes of their coronary
artery disease will be correlated with the number of those aforementioned cells.
Inclusion Criteria:
- Patients having stable coronary artery disease and undergoing either angiography or
angioplasty
Exclusion Criteria:
- Unstable coronary artery disease associated with either EKG changes or elevation of
cardiac enzymes
- Coronary intervention in the past 3 months
- Renal insufficiency
- Malignancy within the past 5 years except non-melanomatous skin cancers
- Recent infection within the past 3 months requiring antibiotic treatment
- Recent surgery requiring anesthesia within the past 3 months
- Having inflammatory disease
- Chemotherapy, radiation therapy or bone marrow stimulants at any time in the past
- Menstruating women
- Recent changes in statin, ACE-Inhs, or Angiotensin receptor blocker doses
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