Intraocular Pressure During Spine Surgery
| Status: | Completed |
|---|---|
| Conditions: | Ocular |
| Therapuetic Areas: | Ophthalmology |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 4/21/2016 |
| Start Date: | December 2007 |
| End Date: | February 2010 |
The Effect of Lactated Ringer's Solution Versus Albumin and the Alpha-2 Agonist Brimonidine Versus Placebo on Intraocular Pressure During Prone Spine Surgery
This study will compare the effect of two intravenous solutions on eye pressure during spine
surgery in the following groups:
Group A - Lactated Ringer's replacement for blood loss and placebo eye drops
Group B - Lactated Ringer's replacement for blood loss and brimonidine eye drops
Group C - Albumin replacement for blood loss and placebo eye drops
Group D - Albumin replacement for blood loss and brimonidine eye drops
surgery in the following groups:
Group A - Lactated Ringer's replacement for blood loss and placebo eye drops
Group B - Lactated Ringer's replacement for blood loss and brimonidine eye drops
Group C - Albumin replacement for blood loss and placebo eye drops
Group D - Albumin replacement for blood loss and brimonidine eye drops
Patients will be administered either brimonidine eye drops, or placebo eye drops,
preoperatively, on the day of surgery and during surgery. Eye pressure will be measured
before surgery, every 30 minutes throughout your surgery and every hour for 4 hours
following surgery. Subjects will be evaluated before surgery and on days 5, 8, 15 after
surgery. During these evaluations, the subject will be asked questions about recovery and
his/her eyes will be checked by an ophthalmologist and vision will be tested.
preoperatively, on the day of surgery and during surgery. Eye pressure will be measured
before surgery, every 30 minutes throughout your surgery and every hour for 4 hours
following surgery. Subjects will be evaluated before surgery and on days 5, 8, 15 after
surgery. During these evaluations, the subject will be asked questions about recovery and
his/her eyes will be checked by an ophthalmologist and vision will be tested.
Inclusion Criteria:
- Spine surgery with instrumentation in prone position expected to last at least 5
hours;
- Anticipated blood loss ≥ 1L
- Age 18-80 years old;
- ASA physical status I-III.
Exclusion Criteria:
- History of increased intraocular pressure or glaucoma;
- Diabetic retinopathy;
- Heart failure or serious left ventricular dysfunction;
- Abnormal preoperative fundus examination;
- Creatinine > 2 mg/dL;
- Patient refuses blood transfusion or albumin administration
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