MRI to Measure Liver Fat Content
| Status: | Completed |
|---|---|
| Conditions: | Gastrointestinal, Hepatitis |
| Therapuetic Areas: | Gastroenterology, Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | December 2007 |
| End Date: | June 2011 |
Validation of (1)H-Magnetic Resonance Spectroscopy for Quantification of Hepatic Triglyceride Content
This study will determine whether a magnetic resonance imaging (MRI) test of the liver can
accurately measure the amount of fat in the liver compared to the results of a liver biopsy.
People 18 years of age and older who are scheduled to have or who have already had a liver
biopsy as part of their medical care within 1 month of enrollment in this study may be
eligible to participate.
Participants undergo an MRI. For this procedure, the subject lies still on a table that
slides into a narrow metal cylinder (the MRI scanner) for 30 to 60 minutes. A special pad or
tube is placed around the abdomen to improve the image of the liver obtained. Earplugs are
placed in the ears to muffle loud thumping and knocking sounds that occur with the
electrical switching of the magnetic field. The findings of the MRI are compared with those
of the liver biopsy.
accurately measure the amount of fat in the liver compared to the results of a liver biopsy.
People 18 years of age and older who are scheduled to have or who have already had a liver
biopsy as part of their medical care within 1 month of enrollment in this study may be
eligible to participate.
Participants undergo an MRI. For this procedure, the subject lies still on a table that
slides into a narrow metal cylinder (the MRI scanner) for 30 to 60 minutes. A special pad or
tube is placed around the abdomen to improve the image of the liver obtained. Earplugs are
placed in the ears to muffle loud thumping and knocking sounds that occur with the
electrical switching of the magnetic field. The findings of the MRI are compared with those
of the liver biopsy.
Percutaneous liver biopsy remains the gold standard test to evaluate hepatic fat content,
fibrosis and cirrhosis, but there is growing interest in the application of magnetic
resonance imaging (MRI) techniques such as (1)H-Magnetic Resonance Spectroscopy ((1)H-MRS)
as a non-invasive approach to quantify these characteristics. The ability to accurately
quantify hepatic metabolites, such as intrahepatic lipid, has important implications for
clinical evaluation and management of patients with liver related diseases and may obviate
the need for liver biopsies in a number of clinical settings. The current proposal is
designed to develop and validate hepatic (1)H-MRS capabilities at the NIH Clinical Center
and to use this technique in a subsequent study to estimate the prevalence of hepatic
steatosis among persons living with HIV/AIDS. In the present study we propose to complete
MRI with (1)H-MRS in 70 adults who will be undergoing percutaneous liver biopsy in order to
establish the ability of (1)H-MRS to accurately assess hepatic fat content compared to
histopathological scoring.
fibrosis and cirrhosis, but there is growing interest in the application of magnetic
resonance imaging (MRI) techniques such as (1)H-Magnetic Resonance Spectroscopy ((1)H-MRS)
as a non-invasive approach to quantify these characteristics. The ability to accurately
quantify hepatic metabolites, such as intrahepatic lipid, has important implications for
clinical evaluation and management of patients with liver related diseases and may obviate
the need for liver biopsies in a number of clinical settings. The current proposal is
designed to develop and validate hepatic (1)H-MRS capabilities at the NIH Clinical Center
and to use this technique in a subsequent study to estimate the prevalence of hepatic
steatosis among persons living with HIV/AIDS. In the present study we propose to complete
MRI with (1)H-MRS in 70 adults who will be undergoing percutaneous liver biopsy in order to
establish the ability of (1)H-MRS to accurately assess hepatic fat content compared to
histopathological scoring.
- INCLUSION CRITERIA:
Age 18+, male or female
Planned liver biopsy or liver biopsy within the past month with pathology samples
available to be read at NIH CC
EXCLUSION CRITERIA:
Known current pregnancy or pregnancy within 6 months
Contraindications to MRI
Subject is deemed unable to comply with requirements of study participation
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
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