Phase I/II Combination With Irinotecan- Erbitux
| Status: | Completed |
|---|---|
| Conditions: | Colorectal Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | May 2008 |
| End Date: | December 2012 |
A Blinded, Randomized, Phase 1/2 Study of Brivanib Alaninate vs Placebo in Combination With Erbitux and Irinotecan K-Ras Wildtype Subjects With Metastatic Colorectal Cancer
Part 1: To define the recommended dose of brivanib that can be safely administered in
combination with Erbitux (Cetuximab) and irinotecan to subjects with advanced metastatic
colorectal cancer (MCRC)
Part 2: To compare median duration of progression free survival (PFS)
combination with Erbitux (Cetuximab) and irinotecan to subjects with advanced metastatic
colorectal cancer (MCRC)
Part 2: To compare median duration of progression free survival (PFS)
Inclusion Criteria:
- Biopsy proven MCRC
- Prior irinotecan allowed
- Prior Erbitux allowed
Exclusion Criteria:
- No prior brivanib
- No prior combination of irinotecan with Erbitux
- No secondary malignancies
- No anti-coagulation therapy
- No prior history of blood clots requiring anti-coagulation
We found this trial at
5
sites
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1441 Eastlake Ave
Los Angeles, California 90033
Los Angeles, California 90033
(323) 865-3000
U.S.C./Norris Comprehensive Cancer Center The USC Norris Comprehensive Cancer Center, located in Los Angeles, is...
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James Graham Brown Cancer Center No one should feel compelled to leave Kentucky to seek...
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