Structural Imaging and Cognitive Functions in Adult Stem Cell Transplant Recipients Treated With Chemotherapy Alone or in Combination With Radiotherapy

Inclusion Criteria:

- Diagnosed with acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL),
acute undifferentiated or biphenotypic leukemia, myelodysplastic syndrome (MDS),
Hodgkin's lymphoma, (HL) or non-Hodgkin's lymphoma (NHL), and in complete remission
at the time of enrollment

- Are scheduled to undergo conditioning treatment with (1) total body radiation (TBI)
and chemotherapy or (2) chemotherapy alone prior to receiving a myeloablative
allogeneic HSCT

- Between 18 and 70 years of age.

- Are English speaking.

- Have capacity to give consent.

Healthy Control Inclusion Criteria:

- Have no diagnosis of cancer except basal cell carcinoma

- Between 18 and 70 years of age.

- Are English speaking.

- Have capacity to give consent

Exclusion Criteria:

- Patients with signs and/or symptoms of central nervous system disease as determined
by their physician or by a brain MRI, either at the time of enrollment or during the
study period.

- With disease progression at the time of enrollment or during the study period

- With self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder
(untreated), bipolar disorder, schizophrenia

- With a history of a neurological disorder, neurodegenerative disease, or traumatic
brain injury with loss of consciousness

- With standard contraindications to MRI examinations

Healthy Control Exclusion Criteria:

- Exposure to chemotherapy or radiation therapy for any medical condition

- With self-reported Axis I psychiatric disorder (DSM-IV), major affective disorder
(untreated), bipolar disorder, schizophrenia

- With a history of neurological disorders, neurodegenerative disease, or traumatic
brain injury with loss of consciousness

- With standard contraindications to MRI examinations