PRO 140 by IV Administration in Adults With HIV-1 Infection
| Status: | Completed |
|---|---|
| Conditions: | Infectious Disease, HIV / AIDS |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | December 2007 |
| End Date: | August 2008 |
A Phase 2a, Randomized, Double-Blind, Placebo-Controlled Study of PRO 140 by Intravenous Administration in Adult Subjects With Human Immunodeficiency Virus Type 1 Infection
The purpose of this study is:
1. To assess and characterize the PK and PD of PRO 140 administered IV
2. To assess the antiviral activity of PRO 140
3. To assess the safety and tolerability of PRO 140
1. To assess and characterize the PK and PD of PRO 140 administered IV
2. To assess the antiviral activity of PRO 140
3. To assess the safety and tolerability of PRO 140
Inclusion Criteria:
1. Males & females, age ≥ 18 years (or minimum adult age as determined by local
regulatory authorities)
2. Screening plasma HIV-1 RNA ≥ 5,000 copies/mL
3. CD4+ T-lymphocyte cell count ≥ 300 cells/mm3 and no documented count < or = 250
cells/mm3
4. Has not taken any anti-retroviral therapy (ART) w/in 12 wks of Early Screening Visit
5. Exclusive CCR5-tropic virus as determined by Trofile™ Assay at Early Screening Visit
6. Clinically normal or "not clinically significant (NCS)" resting electrocardiogram
7. Women of reproductive potential must have a negative serum pregnancy test at Late
Screening Visit & a negative urine pregnancy test w/in 72 hrs prior to first dose of
study medication, & be non-lactating. Male & female subjects must agree not to
participate in a conception process from Early Screening Visit through Day 59.
Exclusion Criteria:
1. CXCR4 tropic virus or dual/mixed tropic (R5X4) virus determined by the Trofile™
Assay.
2. Females who are pregnant, lactating or breastfeeding, or who plan to become pregnant
during the study.
3. History of active hepatitis within the previous 24 wks
4. Prior use of any entry, attachment, CCR5 co-receptor or fusion inhibitor,
experimental or approved.
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