Bevacizumab and Sorafenib in Treating Patients With Recurrent Glioblastoma Multiforme



Status:Completed
Conditions:Brain Cancer, Brain Cancer, Brain Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:5/10/2018
Start Date:September 2008
End Date:February 19, 2014

Use our guide to learn which trials are right for you!

Phase II Trial of Bevacizumab in Combination With Sorafenib in Recurrent Glioblastoma Multiforme

RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different
ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and
help kill them or carry tumor-killing substances to them. Sorafenib may stop the growth of
tumor cells by blocking some of the enzymes needed for cell growth. Bevacizumab and sorafenib
may also stop the growth of tumor cells by blocking blood flow to the tumor. Giving
bevacizumab together with sorafenib may kill more tumor cells.

PURPOSE: This phase II trial is studying the side effects and how well giving bevacizumab
together with sorafenib works in treating patients with recurrent glioblastoma multiforme.

OBJECTIVES:

Primary

- Identify the clinical efficacy of bevacizumab and sorafenib, as measured by 6-month
progression-free survival, in patients with recurrent glioblastoma multiforme.

Secondary

- Assess time to progression of this patient population.

- Assess overall survival of this patient population.

OUTLINE: This is a multicenter study.

Patients receive oral sorafenib once daily on days 1-14 and bevacizumab IV over 30-90 minutes
on day 1. Courses repeat every 14 days in the absence of disease progression or unacceptable
toxicity.

Patients undergo blood and plasma sample collection at baseline and then periodically during
study treatment for translational research studies. Translational research studies include
analysis of circulating endothelial cells and circulating endothelial progenitor cells by
flow cytometry and measurement of angiogenic proteins in plasma by ELISA. DNA and buffy coat
are extracted and collected from the blood samples for pharmacogenetic studies.

Quality of life is assessed at baseline, prior to every other treatment course, and at the
end of treatment.

After completion of study treatment, patients are followed at 28-42 days, every 3 months for
5 years, and then annually for 10 years.

DISEASE CHARACTERISTICS:

- Histologically confirmed glioblastoma multiforme as determined by pre-registration
central pathology review

- Gliosarcoma allowed

- Must have evidence of tumor progression by MRI or CT scan following radiotherapy or
the most recent anti-tumor therapy

- No more than 1 chemotherapy regimen for progressive or recurrent disease

- Bidimensionally measurable or evaluable disease by MRI or CT scan

- No evidence of CNS hemorrhage on baseline CT or MRI

- Patients with T1 hyperintensity confined to the surgical cavity which is felt
likely due to post surgical blood contaminating the intracavity cerebrospinal
fluid or irrigation that have not yet absorbed and which is not felt to
clinically or radiographically represent new spontaneous hemorrhage are eligible

- Patients with old blood products or hemosiderin without a history of spontaneous
bleeding are eligible

PATIENT CHARACTERISTICS:

- ECOG performance status 0-2

- ANC ≥ 1,500/mm³

- Platelet count ≥ 100,000/mm³

- Hemoglobin > 9.0 g/dL

- Total bilirubin ≤ 1.5 times upper limit of normal

- AST ≤ 3 times upper limit of normal

- Creatinine ≤ upper limit of normal

- Urine protein:creatinine ratio < 1 OR urine protein < 1,000 mg by 24-hour urine
collection

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for six months after
completion of study treatment

- Able to complete questionnaire(s) alone or with assistance

- Willing to return to NCCTG enrolling institution for follow-up

- Willing to provide mandatory blood samples for research purposes

- Not immunocompromised (other than that related to the use of corticosteroids)

- No known HIV positivity

- No concurrent uncontrolled illness including, but not limited to, the following:

- Ongoing or active infection

- Symptomatic congestive heart failure

- Unstable angina pectoris

- Cardiac arrhythmia

- Psychiatric illness/social situations that would limit compliance with study
requirements

- No inadequately controlled hypertension (i.e., systolic blood pressure [BP] > 150 mm
Hg or diastolic BP > 100 mm Hg while on antihypertensive medications)

- Patients with well-controlled hypertension are eligible

- No myocardial infarction or unstable angina within the past 6 months

- No congestive heart failure requiring the use of ongoing maintenance therapy for
life-threatening ventricular arrhythmias

- No New York Heart Association class II-IV congestive heart failure

- No significant vascular disease (e.g., aortic aneurysm or aortic dissection)

- No peripheral arterial thrombosis within the past 6 months

- No stroke or transient ischemic attack within the past 6 months

- No history of hypertensive crisis or hypertensive encephalopathy

- No evidence of bleeding diathesis (greater than normal risk of bleeding) or
coagulopathy (in the absence of therapeutic anticoagulation)

- No active or recent history of hemoptysis (i.e., ≥ ½ teaspoon of bright red blood per
episode) within the past 30 days

- No serious, nonhealing wounds, ulcers, or bone fractures

- No condition that impairs the ability to swallow pills (e.g., gastrointestinal tract
disease resulting in an inability to take oral medication or a requirement for IV
alimentation)

- No abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within
the past 6 months

- No significant traumatic injury within the past 28 days

- No known hypersensitivity to any of the components of sorafenib or bevacizumab

- No other active malignancy within the past 3 years, except nonmelanoma skin cancer or
carcinoma in situ of the cervix

- Patients with a history of prior malignancy must not be receiving specific
treatment (other than hormonal therapy) for that malignancy

- No co-morbid systemic illness or other concurrent severe disease that, in the judgment
of the investigator, would make the patient inappropriate for entry into this study or
significantly interfere with the proper assessment of safety and toxicity of the
prescribed study regimen

PRIOR CONCURRENT THERAPY:

- See Disease Characteristics

- At least 12 weeks since prior radiotherapy

- More than 4 weeks since prior chemotherapy (6 weeks for nitrosoureas)

- More than 2 weeks since prior small molecule cell cycle inhibitors

- At least 1 week since prior fixed-dose corticosteroids (or no corticosteroids)

- No prior intratumoral chemotherapy, stereotactic radiosurgery or interstitial
brachytherapy unless there is a separate lesion on MRI that is not part of the prior
treatment field OR there is proof of recurrent disease based on biopsy, MRI
spectroscopy, or PET scan

- No prior antiangiogenic therapy

- No prior surgical procedures affecting absorption

- More than 7 days since prior core biopsy or other minor surgical procedures

- Placement of a vascular access device is allowed

- More than 28 days since prior major surgical procedure or open biopsy

- No concurrent major surgical procedure

- No other concurrent investigational agents

- No concurrent enzyme-inducing antiepileptic drugs (e.g., phenytoin, fosphenytoin,
carbamazepine, phenobarbital, or primidone)

- No other concurrent potent CYP3A4 inducers (e.g., rifampin or St. John's wort)

- No concurrent therapeutic anticoagulation with warfarin

- Prophylactic anticoagulation (i.e., low-dose warfarin) for venous or arterial
access devices allowed provided the INR < 1.5

- Therapeutic anticoagulation with low molecular weight heparin allowed
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