Bevacizumab and Temozolomide or Bevacizumab and Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Carboplatin in Treating Patients With Stage IV Malignant Melanoma That Cannot Be Removed by Surgery



Status:Completed
Conditions:Skin Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:5/3/2018
Start Date:August 2008
End Date:November 2012

Use our guide to learn which trials are right for you!

A Randomized Phase II Trial of Temozolomide (TMZ) and Bevacizumab or ABI-007 (ABX)/Carboplatin (CBDCA) and Bevacizumab in Patients With Unresectable Stage IV Malignant Melanoma

RATIONALE: Drugs used in chemotherapy, such as temozolomide, paclitaxel albumin-stabilized
nanoparticle formulation, and carboplatin, work in different ways to stop the growth of tumor
cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies,
such as bevacizumab, can block tumor growth in different ways. Some block the ability of
tumor cells to grow and spread. Others find tumor cells and help kill them or carry
tumor-killing substances to them. It is not yet known whether bevacizumab is more effective
when given together with temozolomide or paclitaxel albumin-stabilized nanoparticle
formulation and carboplatin in killing malignant melanoma cells.

PURPOSE: This randomized phase II trial is studying the side effects of giving temozolomide
together with bevacizumab and to see how well it works compared with giving bevacizumab
together with paclitaxel albumin-stabilized nanoparticle formulation and carboplatin in
treating patients with stage IV malignant melanoma that cannot be removed by surgery.

OBJECTIVES:

Primary

- To assess the anti-tumor activity, in terms of the percentage of patients who are
treated with these regimens and who are progression-free at 6 months.

- To assess the safety profile of each treatment regimen.

Secondary

- To estimate the response rate in patients treated with these regimens.

- To estimate the distribution of progression-free survival time and overall survival time
of patients treated with these regimens.

Tertiary

- To examine the impact of therapy on angiogenesis and immune homeostasis.

OUTLINE: Patients are stratified according to ECOG performance status (0 vs 1) and location
of metastatic disease (M1a [skin or subcutaneous tissue or lymph node only] vs M1b [lung] vs
M1c [other visceral sites]) and randomized to 1 of 2 treatment arms.

- Arm I: Patients receive oral temozolomide on days 1-5 and bevacizumab IV over 30-90
minutes on days 1 and 15. (closed to accrual 8/21/09)

- Arm II: Patients receive bevacizumab IV over 30-90 minutes on days 1 and 15, paclitaxel
albumin-stabilized nanoparticle formulation IV over 30 minutes on days 1, 8, and 15, and
carboplatin IV over 30 minutes on day 1.

In both arms, treatment repeats every 28 days in the absence of disease progression or
unacceptable toxicity.

Patients undergo blood sample collection periodically for VEGF plasma levels and analysis of
changes in immune homeostasis.

Beginning at study entry, patients are followed up every 3 months for 2 years and then every
6 months for up to 3 years.

- Histologic confirmed diagnosis of malignant melanoma

- Stage IV disease

- Not amenable tosurgery

- Measurable disease with at least one lesion whose longest diameter canbe measured as ≥
20 mm by CT or MRI scans OR ≥ 10 mm by spiral CT

- No disease that is measurable by physical examination only

- No brain metastases per MRI or CT

- No radiographically documented invasion of adjacent organs(duodenum, stomach, etc.) or
tumor invading major blood vessels

- ECOG performance status 0-1

- Life expectancy ≥ 4 months

- ANC ≥ 1,500/mm³

- Platelet count ≥ 100,000/mm³

- Hemoglobin ≥ 9 g/dL (transfusion allowed)

- Creatinine ≤ 1.5 times upper limit of normal (ULN)

- Total bilirubin ≤ 1.5 mg/dL (unless Gilbert syndrome)

- AST ≤ 2.5 times ULN

- Alkaline phosphatase ≤ 2.5 times ULN

- Urine protein:creatinine ratio < 1.0 at screening ORproteinuria < 2+ by urine dipstick
or protein ≤ 1 g by 24-hour urine collection

- Negative serum pregnancy test

- Not pregnant or nursing

- Fertile patients must use effective contraception

- Active infection requiring parenteral antibiotics

- Poorly controlled high blood pressure (≥ 150 mm Hg systolic and/or100 mm Hg diastolic)
despite treatment

- NYHA class II-IV congestive heart failure

- Serious cardiac arrhythmia requiring medication

- Myocardial infarction or unstable angina within the past 6 months

- Clinically significant peripheral vascular disease

- Deep venous thrombosis or pulmonary embolus within the past year

- Active bleeding or pathological conditions that carry high risk of bleeding (e.g.,
known esophageal varices)

- Serious, non-healing wound (including wounds healing by secondary intention), ulcer or
bone fracture

- Abdominal fistula, gastrointestinal perforation, or intraabdominal abscess within the
past 6 months

- History of CNS disease (e.g., primary brain tumor, vascular abnormalities, etc.)

- Clinically significant stroke or TIA within the past 6 months

- Seizures not controlled with standardmedical therapy

- Peripheral neuropathy ≥ grade 2

- History of other malignancy within the past 5 years except basal cell or squamous cell
carcinoma of the skin treatable with local resection only or carcinoma in situ of the
cervix

- Significant traumatic injury within the past 4 weeks

- History of hypertensive crisis or hypertensive encephalopathy

- Active or recent (≤ 30 days) history of hemoptysis (≥ ½ teaspoon of bright red blood
per episode)

- Known hypersensitivity to any of the components of bevacizumab

- Known to be HIV positive

- Current or known history of hepatitis

- Prior adjuvant chemotherapy and/or immunotherapy for this cancer allowed

- No prior treatment with agents disrupting VEGF activity (i.e., bevacizumab,VEGF-trap,
anti-VEGFR Mab)

- No ongoing need for full-dose oral or parenteral anticoagulation

- No ongoing anti-platelet treatment other than low-dose aspirin(i.e., aspirin 81 mg
daily)

- No other investigational agents within the past 4 weeks

- No major surgical procedure or open biopsy within the past 4 weeks

- No fine needle aspirations or core biopsies within the past 7 days

- No prior chemotherapy in the metastatic setting

- No prior treatment with sunitinib malate or sorafenib

- No prior treatment with any taxane-based chemotherapy

- Patients who have had > 25% of their functional bone marrow irradiated are not
eligible for this trial

- No adjuvant radiation therapy within the past 4 weeks

- More than 2 weeks since prior and no concurrent palliative radiation therapy

- No concurrent major surgical procedure

- No concurrent participation in another clinical study for procedures or agents that
treat the same primary study malignancy
We found this trial at
259
sites
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1200 S Cedar Crest Blvd
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100 North Academy Ave
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570-271-6211
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1719 East 19th Avenue
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(303) 839-6000
Presbyterian - St. Luke's Medical Center Presbyterian/St. Luke's Medical Center and the Rocky Mountain Hospital...
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1 Hurley Plaza
Flint, Michigan 48503
(810) 262-9000
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1920 Libal Street
Green Bay, Wisconsin 54307
(920) 433-8889
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19229 Mack Ave
Grosse Pointe Woods, Michigan 48236
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825 N Emporia Ave
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Via Christi Cancer Center at Via Christi Regional Medical Center Via Christi Health's rich history...
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777 Kimole Ln
Adrian, Michigan 49221
517-265-0900
Hickman Cancer Center at Bixby Medical Center At ProMedica Bixby Hospital, we
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Ames, Iowa 50010
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Anchorage, Alaska 99508
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Anderson, South Carolina 29621
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5301 McAuley Drive
Ann Arbor, Michigan 48197
734-712-4673
Saint Joseph Mercy Cancer Center Saint Joseph Mercy Health System is one of Michigan's most...
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300 North Ave
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2222 N. Nevada Avenue
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111 S Grant Avenue
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11850 Blackfoot St. NW Suite 130
Coon Rapids, Minnesota 55433
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Dayton, Ohio 45406
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Dayton, Ohio 45420
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18101 Oakwood Blvd
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Delaware, Ohio 43015
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300 East Locust St., Ste 350
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Findlay, Ohio 45840
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from
Grand Junction, CO
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Grand Rapids, Michigan 49503
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mi
from
Grand Rapids, MI
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