Coronary Heart Disease as Measured by Coronary Calcium Score Among Individuals With Chronic Traumatic Spinal Cord Injury
| Status: | Completed |
|---|---|
| Conditions: | Peripheral Vascular Disease, Cardiology, Cardiology, Hospital, Orthopedic |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Orthopedics / Podiatry, Other |
| Healthy: | No |
| Age Range: | 45 - 70 |
| Updated: | 4/21/2016 |
| Start Date: | September 2007 |
| End Date: | December 2009 |
Prevalence and Risk of Coronary Heart Disease as Measured by Coronary Calcium Score Among Individuals With Chronic Traumatic Spinal Cord Injury(SCI): A Pilot Study
This study includes male subjects age 45 to 70, who have sustained a traumatic Spinal Cord
Injury (SCI) at least 10 years prior. Subjects will be interviewed for demographic data,
including heart disease risk factors. A blood test for cholesterol levels will be drawn. A
CT scan of arteries of the heart will be performed to determine the presence of coronary
calcium, a marker of subclinical Coronary Heart Disease. Scoring of Coronary Calcium or
Coronary Calcium Score (CCS) is automated by the CT scanner. Each subject's Framingham Risk
Score will be calculated; This is an individuals 10 year risk of having a Coronary Heart
Disease event (significant symptoms). In addition, it will be determined if subjects are
being treated for diagnosed dyslipidemia (high cholesterol) according to the National
Cholesterol Educational Program (NCEP) guidelines.
The proposed pilot study aims to better understand the problem of Coronary Heart Disease in
individuals with Spinal Cord Injury, specifically CCS in SCI, when compared to the general
population.
Injury (SCI) at least 10 years prior. Subjects will be interviewed for demographic data,
including heart disease risk factors. A blood test for cholesterol levels will be drawn. A
CT scan of arteries of the heart will be performed to determine the presence of coronary
calcium, a marker of subclinical Coronary Heart Disease. Scoring of Coronary Calcium or
Coronary Calcium Score (CCS) is automated by the CT scanner. Each subject's Framingham Risk
Score will be calculated; This is an individuals 10 year risk of having a Coronary Heart
Disease event (significant symptoms). In addition, it will be determined if subjects are
being treated for diagnosed dyslipidemia (high cholesterol) according to the National
Cholesterol Educational Program (NCEP) guidelines.
The proposed pilot study aims to better understand the problem of Coronary Heart Disease in
individuals with Spinal Cord Injury, specifically CCS in SCI, when compared to the general
population.
Inclusion Criteria:
- Male
- Spinal Cord Injury due to externally inflicted trauma
- > or = 10 years post injury
- American Spinal Injury Association (ASIA) Scale A,B, or C
- 45 to 70 years of age
- Communication and comprehension sufficient for compliance with all testing procedures
- Voluntary informed consent
Exclusion Criteria:
- Spinal Cord Injury of non-traumatic etiology
- Injury < 10 years prior to enrollment
- Known Coronary Heart Disease
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