Study Comparing Bevacizumab + Temsirolimus vs. Bevacizumab + Interferon-Alfa In Advanced Renal Cell Carcinoma Subjects
| Status: | Completed |
|---|---|
| Conditions: | Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | April 2008 |
| End Date: | April 2015 |
Phase 3b, Randomized, Open-label Study Of Bevacizumab + Temsirolimus Vs. Bevacizumab + Interferon-alfa As First-line Treatment In Subjects With Advanced Renal Cell Carcinoma
Primary objective: Comparison of independently assessed progression free survival (PFS) in
subjects administered Bevacizumab + Temsirolimus vs. those administered Bevacizumab +
Interferon-Alfa. Secondary objectives: safety, Investigator assessed PFS, objective response
rate (independently assessed), and overall survival.
subjects administered Bevacizumab + Temsirolimus vs. those administered Bevacizumab +
Interferon-Alfa. Secondary objectives: safety, Investigator assessed PFS, objective response
rate (independently assessed), and overall survival.
Inclusion Criteria:
- Histologically and/or cytologically confirmed to have advanced renal cell carcinoma
(RCC)
- Majority component of conventional clear-cell type is mandatory
- At least 1 measurable lesion (per RECIST)
Exclusion Criteria:
- Prior systemic treatment for RCC
- Evidence of current or prior central nervous system (CNS) metastases
- Cardiovascular disease
- Pregnant or nursing women
- Additional criteria applies
We found this trial at
25
sites
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Cleveland Clinic Cleveland Clinic is committed to principles as presented in the United Nations Global...
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Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
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UCLA Medical Center Founded in 1955, UCLA Medical Center became Ronald Reagan UCLA Medical Center...
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UCLA UCLA's primary purpose as a public research university is the creation, dissemination, preservation and...
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University of Oklahoma The OU Health Sciences Center is composed of seven health-related colleges located...
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California Pacific Medical Center California Pacific Medical Center is one of the largest private, not-for-profit,...
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University of Washington Medical Center University of Washington Medical Center is one of the nation's...
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Virginia Mason Medical Center Established in 1920, Virginia Mason began as an 80-bed hospital with...
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