A Pilot Study to Evaluate Optical Spectroscopy of Pigmented Skin Lesions
| Status: | Completed |
|---|---|
| Conditions: | Skin Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | July 2008 |
| End Date: | November 2013 |
A Pilot Study to Evaluate the Correlation Between Modified Two Layer Diffuse Optical Spectroscopy With the Clinical and Histological Examinations of Pigmented Skin Lesions Based on Physiological Parameters
The incidence of malignant melanoma has increased dramatically in recent decades. In 1930,
the lifetime risk of an individual in the United States developing melanoma was 1 in 1,500.
This has been exponentially increasing over the years with the risk estimated to be 1 in 75
in 2000 . According to the American Cancer Society, approximately 59,580 new cases of
melanoma will be diagnosed in the United States in 2005 and about 7,770 people are expected
to die of the disease.
the lifetime risk of an individual in the United States developing melanoma was 1 in 1,500.
This has been exponentially increasing over the years with the risk estimated to be 1 in 75
in 2000 . According to the American Cancer Society, approximately 59,580 new cases of
melanoma will be diagnosed in the United States in 2005 and about 7,770 people are expected
to die of the disease.
The researcher ucan use special imaging devices to obtain information about a typical mole
and melanoma and use this information to determine the different between malignant and
benign melanized lesions. The imaging devices are, Modified Two Layer Diffuse Optical
Spectroscopy,multi-spectral imaging, and Spatially Modulated Quantitative Spectroscopy can
use to measure atypical moles and melanoma and correlate the results of the biopsy tissue
histology.
The imaging devices can quantify melanin, oxy and deoxy hemoglobin concentration, water,
lipid and reduced scattering coefficients and can compare results to histopathologic.
Atypical moles and melanoma have a different optical profile based on physiological
parameters compared to benign nevus.
and melanoma and use this information to determine the different between malignant and
benign melanized lesions. The imaging devices are, Modified Two Layer Diffuse Optical
Spectroscopy,multi-spectral imaging, and Spatially Modulated Quantitative Spectroscopy can
use to measure atypical moles and melanoma and correlate the results of the biopsy tissue
histology.
The imaging devices can quantify melanin, oxy and deoxy hemoglobin concentration, water,
lipid and reduced scattering coefficients and can compare results to histopathologic.
Atypical moles and melanoma have a different optical profile based on physiological
parameters compared to benign nevus.
Inclusion Criteria:
- 18 years or older.
- Have atypical mole/s and melanoma
Exclusion Criteria:
- Age less than 18 years old.
- have NO atypical mole/s and melanoma
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