Acamprosate for Treatment of Compulsive Behaviors and Craving in Parkinson's Disease
| Status: | Withdrawn |
|---|---|
| Conditions: | Parkinsons Disease, Psychiatric |
| Therapuetic Areas: | Neurology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | August 2006 |
| End Date: | September 2008 |
The purpose of this study is to determine how many patients with Parkinson's disease have
compulsive behaviors, and what types of behaviors they have. This study will also determine
if acamprosate can be used to treat compulsive behaviors in Parkinson's disease patients.
compulsive behaviors, and what types of behaviors they have. This study will also determine
if acamprosate can be used to treat compulsive behaviors in Parkinson's disease patients.
Inclusion Criteria:
1. Idiopathic Parkinson's disease
2. Active dopaminergic therapy at stable dose for one month (levodopa or dopamine
agonist)
3. Able and willing to complete Rating Scales
4. Presence of one or more compulsive behavior based on responses to Rating Scales
(defined as >5 on the SOGS; >17 on the YBOCS-SV and YBOCS-CUV; >1.7 on the SCS for
women and >2.1 on the SCS for men; >15 on the YBOCS-BE, >5.5 on the CQ).
5. Written informed consent
Inclusion criteria (controls):
1. No significant psychiatric disease
2. Able and willing to complete Rating Scales
3. Written informed consent
Exclusion Criteria:
1. No anticipated need for adjustment of medications for Parkinson's disease
2. Current participation in another clinical study
3. History of unstable psychiatric disease (as determined by the Principal Investigator)
4. Women of childbearing age not using appropriate contraceptive methods (oral
contraceptives, condoms, surgery)
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