Positron Emission Tomography (PET) Using Hormone Receptor Ligands in Breast Cancer
| Status: | Completed |
|---|---|
| Conditions: | Breast Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | November 2006 |
| End Date: | June 2013 |
PET Using Hormone Receptor Ligands in Breast Cancer
The purpose of this study is to find a way to learn the hormone receptor status of a tumor
before surgery is done. By testing for the hormone receptor proteins, doctors can find out
if the breast cancer uses hormones to grow. This is important since the hormone receptor
status of a tumor helps doctors decide if extra treatment like chemotherapy or pills are
needed.
before surgery is done. By testing for the hormone receptor proteins, doctors can find out
if the breast cancer uses hormones to grow. This is important since the hormone receptor
status of a tumor helps doctors decide if extra treatment like chemotherapy or pills are
needed.
Inclusion Criteria:
- Male and Female patients
- Aged 18 or older at the time of breast cancer diagnosis
- Patients with invasive breast cancer at least 1 cm in size. Patients who have had a
prior surgical excision are eligible provided there is a residual of at least a 1 cm
area suspected on imaging studies.
- Histopathologic review at MSKCC confirming diagnosis of invasive breast cancer
(ductal, lobular, or inflammatory breast cancer).
- Patients who are operative candidates. Patient will have surgery to include either
mastectomy or lumpectomy. Radiologic assisted excisions such as needle localization
are also eligible.
- Patients with bilateral breast cancer are eligible.
- Patients with metastatic cancer, provided they need surgical biopsy.
- Patients who are undergoing sentinel node mapping (day before or sameday mapping).
- Patient must sign informed consent.
Exclusion Criteria:
- Previous or concurrent malignancy (except basal and squamous skin cancer and stage 0
cervical cancer)
- Patients who are pregnant or nursing
- Patients unable to tolerate PET or PET/CT
- Patients with known active infection, autoimmune or inflammatory disease such as
sarcoidosis, and rheumatoid arthritis.
- Patients with non invasive breast cancer such as DCIS.
- Patients who have received prior radiation therapy to the affected breast.
- Patients who have received prior chemotherapy, including neoadjuvant chemotherapy or
hormonal therapy for breast cancer.
- Patients living in a residential care or correctional facility.
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Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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