Follow-Up Study of Kidney Cancer Patients

Previously we proposed to conduct a follow-up study of kidney cancer in the high risk region
of Central and Eastern Europe. This study was conducted through the follow-up of a group of
patients with kidney cancer, that were previously enrolled in the study entitled, Occupation,
Genetic Susceptibility Kidney Cancer: Central European Case-Controls Study, PI Dr. Wong-Ho
Chow, OEEB, DCEG, NCI, protocol No 01-C-NO63, a study for which field work and data analyses
of the case control study were completed. We had originally planned to conduct the follow-up
study in seven centers in four countries, including Romania, Poland, Russia, and the Czech
Republic. In each center, cancer-related information was to be extracted from vital
statistics, cancer registry, and/or medical records. For deceased patients, next-of-kin were
to be interviewed using a brief questionnaire.

A pilot study was conducted to determine the feasibility of collecting survival information
including 5-year survival status, date of death, cause of death, and date of last follow-up
if alive from 220 cases across the seven collaborating centers. The feasibility of extracting
additional data including surgical and medical treatment procedures used to treat primary
disease, the recurrence and progression of primary disease was also determined. However,
based on results obtained from the pilot study, we determined that it is feasible to collect
follow-up data from kidney cancer cases from four centers in the Czech Republic and one
center in both Poland and Russia.

Medical records/archives for Romanian cases were located in hospitals that were completely
destroyed during reconstruction therefore, it was impossible to collect any information from
this subset of patients. Exclusion of these records will not affect study power since most of
the cases were from the Czech Republic. The objective of our proposed study remains the
same:( 1) to assess the 5-year survival status of kidney cancer patients in the Central and
Easter European Renal Cell Carcinoma Study; (2) to examine prevalence of recurrent disease
and progression; (3) to investigate additional patient-tumor-and genetic determinant of
5-year survival in cases.

- INCLUSION CRITERIA:

To be eligible for this study, patients needed to have participated as a histologically
confirmed renal cancer case in the previous case-control study entitled Central European
Renal Cancer Case-Control (CEERCC) Study which was completed in 2002.

EXCLUSION CRITERIA:

Children less than 18 are not eligible to participate in this study because there were no
kidney cancer cases observed in the CEERCC Study that were less than 18 years of age.

American Indian/Alaskan Native, Asian, Black or African American, Hispanic or Latino, and
Native Hawaiian or Pacific Islander.