Utility of [F-18] fluoroDOPA for Neonatal Hyperinsulinism
| Status: | Completed |
|---|---|
| Conditions: | Endocrine |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | Any - 18 |
| Updated: | 2/21/2018 |
| Start Date: | December 2004 |
| End Date: | February 2018 |
Localization of Focal Forms of Hyperinsulinism of Infancy With 18F-labeled L-fluoro-DOPA PET Scan
Children with congenital hyperinsulinism (CHI) have low blood sugar, and some of these
children may require surgery. In this study, researchers affiliated with the University of
Pennsylvania will test how well a radioactive drug (called F-DOPA) can detect a form of
hyperinsulinism that may be cured by surgery. Eligible participants in this study will have
positron emission tomography (PET) scans with F-DOPA prior to surgery.
children may require surgery. In this study, researchers affiliated with the University of
Pennsylvania will test how well a radioactive drug (called F-DOPA) can detect a form of
hyperinsulinism that may be cured by surgery. Eligible participants in this study will have
positron emission tomography (PET) scans with F-DOPA prior to surgery.
For children with congenital hyperinsulinism (CHI), low blood sugar is caused by cells in the
pancreas that release too much insulin. Some children with CHI have these cells throughout
their pancreas; others have them located in specific areas of the pancreas. Children who have
them located in specific areas of the pancreas may be cured with surgery. F-DOPA is a
radioactive drug that may go to these very cells. F-DOPA can also be used for positron
emission tomography (or PET), an imaging technique used in nuclear medicine departments. In
this study, researchers will test the possibility of using PET with F-DOPA in the diagnosis
of children with hyperinsulinism.
pancreas that release too much insulin. Some children with CHI have these cells throughout
their pancreas; others have them located in specific areas of the pancreas. Children who have
them located in specific areas of the pancreas may be cured with surgery. F-DOPA is a
radioactive drug that may go to these very cells. F-DOPA can also be used for positron
emission tomography (or PET), an imaging technique used in nuclear medicine departments. In
this study, researchers will test the possibility of using PET with F-DOPA in the diagnosis
of children with hyperinsulinism.
Inclusion Criteria:
- Any age, but primarily infants 0-6 months.
- Children with confirmed diagnosis of congenital hyperinsulinism.
Exclusion Criteria:
- Cases in which surgery will not be considered by parents or guardians.
We found this trial at
1
site
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
Click here to add this to my saved trials
