Axitinib (AG 013736) As Second Line Therapy For Metastatic Renal Cell Cancer



Status:Completed
Conditions:Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:1/11/2019
Start Date:September 3, 2008
End Date:February 25, 2016

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Trial Summary
Trial Overview
Inclusion Criteria

AXITINIB (AG-013736) AS SECOND LINE THERAPY FOR METASTATIC RENAL CELL CANCER: AXIS TRIAL

The study is designed to demonstrate that axitinib (AG-013736) is superior to sorafenib in
delaying tumor progression in patients with metastatic renal cell cancer after failure of one
first line regimen.


Inclusion Criteria:

- Histologically or cytologically confirmed renal cell cancer with a component of clear
cell subtype, with metastasis

- Evidence of measurable disease

- Must have failed one prior systemic first-line regimen for metastatic renal cell
cancer

Exclusion Criteria:

- Prior treatment for metastatic renal cell cancer with more that one systemic first
line therapy

- Major surgery less than 4 weeks or radiation less than 2 weeks of starting study drug
We found this trial at
147
sites
Beth Israel Deaconess Medical Center
330 Brookline Ave
Boston, Massachusetts 02215
617-667-7000
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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Massachusetts General Hospital
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
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Boston, MA
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Montefiore Medical Center
3550 Jerome Avenue
Bronx, New York 10467
(718) 920-4321
Montefiore Medical Center As the academic medical center and University Hospital for Albert Einstein College...
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Bronx, NY
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Florida Cancer Specialists
3840 Broadway
Fort Myers, Florida 33901
(239) 275-6400
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Fort Myers, FL
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Vanderbilt-Ingram Cancer Center
2220 Pierce Ave
Nashville, Tennessee 37232
615-936-8422
Vanderbilt-Ingram Cancer Center The Vanderbilt-Ingram Cancer Center, located in Nashville, Tenn., brings together the clinical...
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Vanderbilt University Medical Center
1211 Medical Center Dr
Nashville, Tennessee 37232
(615) 322-5000
Vanderbilt Univ Med Ctr Vanderbilt University Medical Center (VUMC) is a comprehensive healthcare facility dedicated...
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M.D. Anderson Cancer Center at Orlando
1400 South Orange Avenue
Orlando, Florida 32806
(407) 648-3800
M.D. Anderson Cancer Center at Orlando For more than twenty years, our cancer center has...
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Orlando, FL
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Orlando Regional Medical Center
1414 Kuhl Avenue
Orlando, Florida 32806
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Orlando, FL
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Seattle Cancer Care Alliance
825 Eastlake Ave E
Seattle, Washington 98109
(206) 288-7222
Seattle Cancer Care Alliance Seattle Cancer Care Alliance (SCCA) is a cancer treatment center that...
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Seattle, WA
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Cancer Centers of the Carolinas - Seneca
131 Lila Doyle Drive
Seneca, South Carolina 29672
(864) 888-3717
Cancer Centers of the Carolinas - Seneca Cancer Centers of the Carolinas is now Cancer...
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Seneca, SC
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University of Michigan Health System
1500 E Medical Center Dr
Ann Arbor, Michigan 48109
(734) 936-4000
University of Michigan Health System The University of Michigan is home to one of the...
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Ann Arbor, MI
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Virginia Cancer Specialists, PC
Arlington, Virginia 22205
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Arlington, VA
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Peachtree Hematology-Oncology Consultants
Atlanta, Georgia 30318
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Atlanta, GA
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Rocky Mountain Cancer Centers
Aurora, Colorado 80012
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University of Colorado Cancer Center
Aurora, Colorado 80045
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University of Colorado Denver: Division of Medical Oncology
Aurora, Colorado 80045
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Texas Oncology - Austin Midtown
Austin, Texas 78705
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Austin, TX
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Texas Oncology - Central Midtown
Austin, Texas 78705
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Texas Oncology-Austin Central
Austin, Texas 78731
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Texas Oncology - South Austin
Austin, Texas 78745
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Texas Oncolgoy - Austin North
Austin, Texas 78758
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Texas Oncology, PA - Austin Northwest
Austin, Texas 78759
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Texas Oncology, P.A.
Bedford, Texas 76022
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Bedford, TX
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Mountain States Tumor Institute
Boise, Idaho 83712
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Florida Cancer Specialists
Bonita Springs, Florida 34135
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Rocky Mountain Cancer Centers, Site #191
Boulder, Colorado 80303
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Florida Cancer Specialists
Bradenton, Florida 34209
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East Valley Hematology and Oncology Medical Group
Burbank, California 91505
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Maurice Berkowtiz, MD
Burbank, California 91505
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Florida Cancer Specialists
Cape Coral, Florida 33914
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Cental Indiana Cancer Centers
Carmel, Indiana 46032
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Carmel, IN
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Raleigh Hematology Oncology Associates
Cary, North Carolina 27511
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Cary, NC
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Texas Oncology, PA - Cedar Park
Cedar Park, Texas 78613
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Medical University of South Carolina
171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
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Chattanooga Oncology Hematology Associates
Chattanooga, Tennessee 37404
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Virginia Oncology Associates
Chesapeake, Virginia 23320
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Chesapeake, VA
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Case Western Reserve Univ
10900 Euclid Ave
Cleveland, Ohio 44106
216-368-2000
Case Western Reserve Univ Continually ranked among America's best colleges, Case Western Reserve University has...
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Cleveland Clinic Foundation
2049 E 100th St
Cleveland, Ohio 44106
(216) 444-2200
Cleveland Clinic Foundation The Cleveland Clinic (formally known as The Cleveland Clinic Foundation) is a...
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Rocky Mountain Cancer Centers
Colorado Springs, Colorado 80907
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Missouri Cancer Associates
Columbia, Missouri 65201
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Columbia, MO
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Ohio State University Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
Columbus, Ohio 43210
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James Care in Kenny
2650 Kenny Road
Columbus, Ohio 43221
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Ohio State University
281 W. Lane Ave
Columbus, Ohio 43210
(614) 292-6446
Ohio State University The Ohio State University’s main Columbus campus is one of America’s largest...
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Texas Oncology-Baylor Charles A. Sammons Cancer Center
Dallas, Texas 75246
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University of Miami Sylvester at Deerfield Beach
Deerfield Beach, Florida 33442
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Deerfield Beach, FL
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Rocky Mountain Cancer Centers, LLP
Denver, Colorado 80218
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Denver, CO
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Rocky Mountain Cancer Centers
Denver, Colorado 80218
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Karmanos Cancer Institute
Detroit, Michigan 48201
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Detroit, MI
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Agajanian Institute of Oncology and Hematology
Downey, California 90241
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Downey, CA
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Investigational Chemotherapy Services
Durham, North Carolina 27710
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Durham, NC
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Duke Univ Med Ctr
2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
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Cancer Centers of the Carolinas
Easley, South Carolina 29640
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Easley, SC
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Albermarie Hospitals
1144 North Road Street
Elizabeth City, North Carolina 27909
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Elizabeth City, NC
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Virginia Oncology Associates
Elizabeth City, North Carolina 27909
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Elizabeth City, NC
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Florida Cancer Specialists
Englewood, Florida 34223
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Englewood, FL
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Oncology Associates of Oregon, PC
Eugene, Oregon 97401
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Eugene, OR
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Virginia Cancer Specialists, PC
8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
(703) 280-5390
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
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Weisberg Cancer Treatment Center
Farmington Hills, Michigan 48334
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Central Indiana Cancer Centers
Fishers, Indiana 46037
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Fishers, IN
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Investigation Products Center (IPC)
Fort Worth, Texas 76177
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Investigational Products Center (IPC)
Fort Worth, Texas 76177
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US Oncology Research and Clinical Pharmacy
Fort Worth, Texas 76177
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Tennessee Oncology, PLLC
Franklin, Tennessee 37067
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Franklin, TN
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Vanderbilt-Ingram Cancer Center - Cool Springs
Franklin, Tennessee 37067
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Franklin, TN
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Mountain States Tumor Institute
Fruitland, Idaho 83619
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Virginia Cancer Specialists, PC
Gainesville, Virginia 20155
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Tennessee Oncology, PLLC
Gallatin, Tennessee 37066
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Gallatin, TN
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Los Angeles Hematology Oncology Medical Group
Glendale, California 91206
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Glendale, CA
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Cental Indiana Cancer Centers
Greenfield, Indiana 46140
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Greenfield, IN
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Cancer Centers of the Carolinas
Greenville, South Carolina 29605
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Greenville, SC
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Hematology and Oncology Associates of SC, LLC - Eastside Medical Center
Greenville, South Carolina 29615
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Greenville, SC
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The Cancer Center at Hackensack University Medical Center - The Hillcrest Building
Hackensack, New Jersey 07601
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Hackensack University Medical Center
30 Prospect Ave
Hackensack, New Jersey 07601
(201) 996-2000
Hackensack University Medical Center Hackensack University Medical Center, part of the Hackensack University Health Network,...
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The Cancer Center, Hackensack University Medical Center
Hackensack, New Jersey
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Virginia Oncology Associates
Hampton, Virginia 23666
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Hampton, VA
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Comprehensive Cancer Centers of Nevada
Henderson, Nevada
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Henderson, NV
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Tennessee Oncology, PLLC
Hermitage, Tennessee 37076
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Hermitage, TN
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Penn State Milton S. Hershey Medical Center
500 University Dr
Hershey, Pennsylvania 17033
(717) 531-6955
Penn State Milton S. Hershey Medical Center Penn State Milton S. Hershey Medical Center, Penn...
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Chattanooga Oncology & Hematology Associates
Hixson, Tennessee 37343
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Hixson, TN
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Genitourinary Cancer Center
Houston, Texas 77030
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Houston, TX
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University of Texas M.D. Anderson Cancer Center
1515 Holcombe Blvd
Houston, Texas 77030
 713-792-2121
University of Texas M.D. Anderson Cancer Center The mission of The University of Texas MD...
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Central Indiana Cancer Centers
Indianapolis, Indiana 46227
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Indianapolis, IN
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Rocky Mountain Cancer Centers
Lakewood, Colorado 80228
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Lakewood, CO
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Nevada Cancer Institute
Las Vegas, Nevada 89135
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Las Vegas, NV
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Comprehensive Cancer Centers of Nevada
9280 W. Sunset Road Suite 100
Las Vegas, Nevada 89148
702.952.1251
Comprehensive Cancer Centers of Nevada Comprehensive Cancer Centers of Nevada (CCCN) is the award-winning multidisciplinary...
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Tennessee Oncology, PLLC
Lebanon, Tennessee 37087
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Lebanon, TN
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Virginia Cancer Specialists, PC
Leesburg, Virginia 20176
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Rocky Mountain Cancer Centers
Littleton, Colorado 80120
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Littleton, CO
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Rocky Mountain Cancer Centers
Lone Tree, Colorado 80124
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Rocky Mountain Cancer Centers
Longmont, Colorado 80501
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Longmont, CO
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Los Angeles Hematology/Oncology Medical Group
Los Angeles, California 90017
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Lac & Usc Medical Center
Los Angeles, California 90033
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USC Norris Cancer Hospital and Clinics
Los Angeles, California 90033
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Kenmar Research Institute
Los Angeles, California 90057
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Metropolitan Hematology Oncology Medical Group
Los Angeles, California 90057
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UCLA
Los Angeles, California 90095
(310) 825-4321
UCLA UCLA's primary purpose as a public research university is the creation, dissemination, preservation and...
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Ronald Regan UCLA Medical Center
Los Angeles, California 90095
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Monarch
Mayfield Heights, Ohio 44124
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Loyola University of Chicago, Cardinal Bernardin Cancer Center
Maywood, Illinois 60153
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Maywood, IL
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Lake University - Ireland Cancer Center (LUICC)
Mentor, Ohio 44060
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Mentor, OH
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Mountain States Tumor Institute
Meridian, Idaho 83642
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