Ranibizumab Injections to Treat Macular Telangiectasia Without New Blood Vessel Growth
| Status: | Completed |
|---|---|
| Conditions: | Cardiology |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | May 2008 |
| End Date: | March 2011 |
Pilot Study of Intravitreal Injection of Ranibizumab for Macular Telangiectasia Without Neovascularization (MACTEL 2)
This study will examine whether the drug ranibizumab (Lucentis) can help prevent vision loss
in people with macular telangiectasia, a condition in which new blood vessels grow in the
retina at the back of the eye and can leak. Such changes in blood vessels are seen in other
diseases associated with changes in a body chemical called vascular endothelial growth
factor (VEGF). Ranibizumab is an anti-VEGF drug that is effective in treating another eye
disease, age-related macular degeneration, with similar changes in eye blood vessels.
People 18 years of age and older with macular telangiectasia in both eyes with no new blood
vessel growth in either eye may be eligible for this study. They must have vision better
than 20/400 in the study eye.
Participants undergo the following procedures:
- Ranibizumab injections in the study eye at least four times over 12 weeks. Depending on
the response to treatment and the side effects, additional injections may be given
every 4 weeks for up to 1 year. The eye is numbed before the injection and the eye area
is cleaned with an antiseptic. Antibiotic drops are used for 3 days following the
injection to prevent infection.
- Evaluations before starting treatment, at the time of each injection, and 8 weeks after
the last treatment:
- History and physical examination.
- Eye examination with dilation, microperimetry and photography: The eye examination
measures visual acuity, eye pressure and eye movements. For the microperimetry
test, subjects sit in front of a computer screen and press a button when they see
a light on the screen. Measurements and photographs of the retina are also taken.
- Fluorescein and indocyanine green angiography to examine the blood vessels in the
eye: A dye called fluorescein or indocyanine green is injected into a vein in the
arm. The dye travels through the veins to the blood vessels in the eyes. A camera
takes pictures of the dye as it flows through the blood vessels.
- Pregnancy test: Women who are able to become pregnant have a urine pregnancy test
before each ranibizumab injection.
in people with macular telangiectasia, a condition in which new blood vessels grow in the
retina at the back of the eye and can leak. Such changes in blood vessels are seen in other
diseases associated with changes in a body chemical called vascular endothelial growth
factor (VEGF). Ranibizumab is an anti-VEGF drug that is effective in treating another eye
disease, age-related macular degeneration, with similar changes in eye blood vessels.
People 18 years of age and older with macular telangiectasia in both eyes with no new blood
vessel growth in either eye may be eligible for this study. They must have vision better
than 20/400 in the study eye.
Participants undergo the following procedures:
- Ranibizumab injections in the study eye at least four times over 12 weeks. Depending on
the response to treatment and the side effects, additional injections may be given
every 4 weeks for up to 1 year. The eye is numbed before the injection and the eye area
is cleaned with an antiseptic. Antibiotic drops are used for 3 days following the
injection to prevent infection.
- Evaluations before starting treatment, at the time of each injection, and 8 weeks after
the last treatment:
- History and physical examination.
- Eye examination with dilation, microperimetry and photography: The eye examination
measures visual acuity, eye pressure and eye movements. For the microperimetry
test, subjects sit in front of a computer screen and press a button when they see
a light on the screen. Measurements and photographs of the retina are also taken.
- Fluorescein and indocyanine green angiography to examine the blood vessels in the
eye: A dye called fluorescein or indocyanine green is injected into a vein in the
arm. The dye travels through the veins to the blood vessels in the eyes. A camera
takes pictures of the dye as it flows through the blood vessels.
- Pregnancy test: Women who are able to become pregnant have a urine pregnancy test
before each ranibizumab injection.
Retinal telangiectasis is a group of rare, idiopathic retinal vascular anomalies affecting
the retinal capillaries in which irregular capillary dilation and incompetence occur in the
macula. This is the group 2 in the Gass classification of idiopathic juxtafoveal
telangiectasia in which fluorescein angiography showed leakage with capillary dilation.
These patients typically are diagnosed in their fifth or sixth decade of life. Both sexes
may be affected. Minimal exudation, superficial retinal crystalline deposits, and
right-angle venules characterize this disorder. The pathogenesis of the disease is unknown.
Because of the leakage of the retinal vessels and also the finding of neovascularization, it
is possible that vascular endothelial growth factor (VEGF) may be implicated in this
disease.
The purpose of this study is to evaluate the possible role of ranibizumab for the treatment
of eight participants with macular telangiectasia with hyperfluorescence on fluorescein
angiography, with vision better than 20/400, without neovascularization. The primary outcome
of this study will be the proportion of participants that lose 15 letters or more in ETDRS
BCVA at 12 months compared with baseline. The secondary outcomes measured at one year will
include the proportion of participants who lose 10 letters or more, the mean change in ETDRS
BCVA, the change in central retinal thickness, the extent of fluorescein leakage, the change
in fundus autofluorescence, change in size of neovascular membrane and the change in central
retinal sensitivity. This is a pilot study designed to evaluate the feasibility and
potential efficacy of treating patients with macular telangiectasia in a larger, phase III
study within the organization of the MAC TEL Research Group, sponsored by the Lowy
Foundation. Currently, the research group is enrolling 200 patients affected with this
condition for a natural history study in 22 international clinical centers.
the retinal capillaries in which irregular capillary dilation and incompetence occur in the
macula. This is the group 2 in the Gass classification of idiopathic juxtafoveal
telangiectasia in which fluorescein angiography showed leakage with capillary dilation.
These patients typically are diagnosed in their fifth or sixth decade of life. Both sexes
may be affected. Minimal exudation, superficial retinal crystalline deposits, and
right-angle venules characterize this disorder. The pathogenesis of the disease is unknown.
Because of the leakage of the retinal vessels and also the finding of neovascularization, it
is possible that vascular endothelial growth factor (VEGF) may be implicated in this
disease.
The purpose of this study is to evaluate the possible role of ranibizumab for the treatment
of eight participants with macular telangiectasia with hyperfluorescence on fluorescein
angiography, with vision better than 20/400, without neovascularization. The primary outcome
of this study will be the proportion of participants that lose 15 letters or more in ETDRS
BCVA at 12 months compared with baseline. The secondary outcomes measured at one year will
include the proportion of participants who lose 10 letters or more, the mean change in ETDRS
BCVA, the change in central retinal thickness, the extent of fluorescein leakage, the change
in fundus autofluorescence, change in size of neovascular membrane and the change in central
retinal sensitivity. This is a pilot study designed to evaluate the feasibility and
potential efficacy of treating patients with macular telangiectasia in a larger, phase III
study within the organization of the MAC TEL Research Group, sponsored by the Lowy
Foundation. Currently, the research group is enrolling 200 patients affected with this
condition for a natural history study in 22 international clinical centers.
- INCLUSION CRITERIA:
- Participant must understand and sign the informed consent.
- Participant must be at least 18 years of age.
- Participant must have macular telangiectasia in both eyes.
- Participant must have vision loss of better than 20/400 in the study eye.
- Participant must have clear ocular media and adequate pupillary dilation to permit
good quality stereoscopic fundus photography.
- All women of childbearing potential must have a negative urine pregnancy test at
baseline, and be willing to undergo testing immediately prior to each injection and
monthly for at least two months following the last dose of ranibizumab.
EXCLUSION CRITERIA:
- Safety and toxicity of ranibizumab have not yet been investigated in children.
Further, it is unlikely that younger participants will be able to comply with all
examinations and intravitreal injections. Therefore, participants below the age of 18
will be excluded from participation in the study. This ocular condition is not
commonly found in participants below the age of 18.
- Participant has neovascularization in either eye.
- History (within past five years) or evidence of severe cardiac disease (apparent in
electrocardiogram abnormalities, clinical history of unstable angina, acute coronary
syndrome, myocardial infarction, revascularization procedure within six months prior
to baseline, atrial or ventricular tachyarrythmias requiring ongoing treatment).
- History of stroke within 12 months of study entry.
- History within the past 30 days of a chronic ocular or periocular infection
(including any history of ocular herpes zoster).
- Current acute ocular or periocular infection.
- Any major surgical procedure within one month of study entry.
- Known serious allergies to fluorescein dye.
- Previous participation in a clinical trial (for either eye) involving anti-angiogenic
drugs (pegaptanib, ranibizumab, bevacizumab, anecortave acetate, Protein Kinase C
inhibitors, etc.).
- Previous intravitreal drug delivery (e.g., intravitreal corticosteroid injection or
device implantation) in the study eye.
- History of vitrectomy surgery in the study eye.
- History of glaucoma filtering surgery in the study eye.
- History of corneal transplant in the study eye.
- Pregnancy (positive pregnancy test) or lactation and premenopausal women not using
adequate contraception. The following are considered effective means of
contraception: surgical sterilization or use of oral contraceptives, barrier
contraception with either a condom or diaphragm in conjunction with spermicidal gel,
an IUD, or contraceptive hormone implant or patch.
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
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