Phase 2b Study to Assess the Safety and Tolerability of IV Tonapofylline in Subjects With Acute Decompensated Heart Failure (ADHF) and Renal Insufficiency

Inclusion Criteria:

- Previous diagnosis of heart failure.

- Must have ADHF, requiring hospitalization, with clinical evidence for volume overload

Exclusion Criteria:

- History of an allergic reaction to any xanthine-containing substance.

- History of seizure

- History of stroke

- Myocardial infarction

- Uncorrected hemodynamically significant primary valvular disease or known Obstructive
or restrictive cardiomyopathy.

- Serious systemic infection

- Major surgical procedures within 30 days

- Acute coronary syndrome

- Cardiogenic shock

- Baseline body weight >150 kg

- Participation in any other investigational study of drugs or devices within 30 days
prior to Screening

- Nursing mothers, pregnant women, or women planning on becoming pregnant during the
study

- Presence of any clinically significant condition that might interfere with optimal
safe participation in this study