FFA Hypertension and Inflammation in Lean and Obese Subjects
| Status: | Completed |
|---|---|
| Conditions: | High Blood Pressure (Hypertension), Obesity Weight Loss |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/21/2016 |
| Start Date: | April 2009 |
| End Date: | June 2011 |
Free Fatty Acids-Induced Hypertension, Endothelial Dysfunction, Inflammation, Insulin Resistance, and Autonomic Dysfunction in Lean and Obese Subjects
Although a large number of obese patients develop high blood pressure, the cause is unknown.
The purpose of this study is to look at the effect of high fatty acids (a type of fat) in
the development of high blood pressure in obese people.
The purpose of this study is to look at the effect of high fatty acids (a type of fat) in
the development of high blood pressure in obese people.
Recent studies indicate that increased levels of a circulating fat (free fatty acids or
FFAs) increases blood pressure, impairs endothelial (vascular) function, and increases
inflammatory markers in subjects with and without diabetes. The effects of FFA on blood
pressure and vasculature have not been fully investigated. A group of 12 obese nondiabetic,
normotensive subjects will be admitted to the Grady Clinical Research Center (GCRC) on
separate 4 occasions. Research subjects will receive, in random order, a 8-hour intravenous
(IV) infusion of Intralipid 20% at 40 mL/h (a fat solution), 8-hour IV infusion of normal
saline at 40 mL/h, 8-hour IV infusion of dextrose (sugar) 10% at 40 mL/h, and a 8-hour
intravenous (IV) infusion combination of Intralipid 20% and dextrose 10% at 40mL/h.
FFAs) increases blood pressure, impairs endothelial (vascular) function, and increases
inflammatory markers in subjects with and without diabetes. The effects of FFA on blood
pressure and vasculature have not been fully investigated. A group of 12 obese nondiabetic,
normotensive subjects will be admitted to the Grady Clinical Research Center (GCRC) on
separate 4 occasions. Research subjects will receive, in random order, a 8-hour intravenous
(IV) infusion of Intralipid 20% at 40 mL/h (a fat solution), 8-hour IV infusion of normal
saline at 40 mL/h, 8-hour IV infusion of dextrose (sugar) 10% at 40 mL/h, and a 8-hour
intravenous (IV) infusion combination of Intralipid 20% and dextrose 10% at 40mL/h.
Inclusion Criteria:
- Males or females
- Obese subjects (body mass index (BMI) ≥ 30 kg/m^2)
- 18 and 65 years
- Blood pressure reading < 140/80 mm Hg and no prior history of hypertension
Exclusion Criteria:
- History of diabetes mellitus
- History of hypertension
- Fasting triglyceride levels > 250 mg/dL
- Liver disease (ALT 2.5x > upper limit of normal)
- Serum creatinine ≥1.5 mg/dL
- Smokers, drug or alcohol abuse
- Mental condition rendering the subject unable to understand the scope and possible
consequences of the study
- Female subjects who are pregnant or breast feeding
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