The Use of L-Carnitine And CoQ10 Supplements In the Treatment of Cyclic Vomiting Syndrome (CVS)



Status:Enrolling by invitation
Healthy:No
Age Range:Any
Updated:5/4/2016
Start Date:October 2007
End Date:December 2016

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Trial Summary
Trial Overview
Inclusion Criteria

Co-Enzyme Q10, L-Carnitine and Amitriptyline Usage in Cyclic Vomiting Syndrome (CVS): A Research Study

This is a study with the principle goal being to learn about the use of L-Carnitine and
CoQ10, two vitamin supplements that are currently being used to treat Cyclic Vomiting
Syndrome, largely initiated by parents. We want to learn how effective these supplements are
compared to standard treatment, at what dose, and what onset of action in order to initiate
future prospective study on these supplements.


Inclusion Criteria:

- 3 discrete episodes of vomiting

- normal health between episodes

- stereotypical clinical pattern

- no abnormal test results to account for vomiting (see exclusion criteria)

Exclusion Criteria:

- abnormal UGI with small bowel follow-through revealing an anatomic anomaly,
inflammatory or obstructive

- Significantly abnormal endoscopic biopsies (moderate to severe esophagitis, H.
pylori)

- Abnormal abdominal ultrasound revealing hydronephrosis, cholelithiasis, pancreatitis

- Positive screening for endocrine disorder (diabetic ketoacidosis, Addison's)

- Positive screening for inborn errors of metabolism (hypoglycemia, lactic acidosis,
hyperammonemia, organic acidemia, amino aciduria, elevated beta-ALA, porphobilinogen)
We found this trial at
1
site
Children's Hospital of Wisconsin
9000 W Wisconsin Ave #270
Milwaukee, Wisconsin 53226
(414) 266-2000
Children's Hospital of Wisconsin Nothing matters more than our children. At Children's Hospital of Wisconsin,...
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from
Milwaukee, WI
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