Aprepitant With Dexamethasone Versus Ondansetron With Dexamethasone for PONV Prophylaxis in Patients Having Craniotomy

Inclusion Criteria:

A patient is eligible for inclusion in this study if all of the following criteria apply:

- Age: 18-75 years of age

- Surgery: craniotomy under general anesthesia.

- American Society of Anesthesiologists (ASA) Status: ASA: I, II, or III

- Language: Fluent in the English language

- Informed Consent: Written informed consent must be obtained.

Exclusion Criteria:

A patient will not be eligible for inclusion in this study if any one or more of the
following criteria apply within thirty days of patient enrollment in this clinical trial:

- Medical: Any condition that may impair a patient's ability to complete any of the
study assessments or confound interpretation of results.

- Hypersensitivity: Patient has a known immediate or delayed hypersensitivity reaction
or known idiosyncrasy to any of the two study medications, ondansetron, or
aprepitant.

- Other Drugs: Patients should not be taking medications with known antiemetic
properties (phenothiazines, butyrophenones, antihistamines), nor should they receive
metoclopramide, or other antiemetics preoperatively or 12 hours before the scheduled
surgical procedure.

- Pregnant or lactating females: A pregnancy test will be performed within 24 hours of
entering the study for females of childbearing potential.

- Substance Abuse: Clinically significant abuse of substances (alcohol, illicit or
prescribed medications) such that the patient is unable to provide informed consent
or reliably complete any of the study assessments.

- Psychiatric Disease: History of a psychiatric illness that may impair the patient's
ability to provide informed consent or complete any of the study assessments.

- Nausea verbal rating score (VRS): A VRS nausea score > 3 (scale 0-10) in the
preoperative holding area before pretreatment with the study medications.