An Efficacy Study of MORAb-009 (Amatuximab) in Subjects With Pleural Mesothelioma
| Status: | Completed |
|---|---|
| Conditions: | Lung Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | December 2008 |
| End Date: | January 2014 |
An Open-Label Clinical Trial of MORAb-009 in Combination With Pemetrexed and Cisplatin in Subjects With Mesothelioma
This research is being done to find out if pemetrexed and cisplatin work better when given
together with an experimental drug called MORAb-009 in patients with malignant pleural
mesothelioma.
together with an experimental drug called MORAb-009 in patients with malignant pleural
mesothelioma.
Primary Inclusion Criteria:
- Confirmed diagnosis of malignant pleural mesothelioma (MPM) with the following
characteristics: unresectable disease (or otherwise not a candidate for curative
surgery); epithelial type or biphasic (mixed) type with low sarcomatous content.
- Measurable disease at Screening by computed tomography (CT)(or magnetic resonance
imaging [MRI]).
- KPS of greater than or equal to 70% at Screening.
- Life expectancy of at least 3 months
Primary Exclusion Criteria:
- Sarcomatous type of mesothelioma
- Prior systemic therapy or radiotherapy for MPM; local radiotherapy for symptom
control (ie, non-curative intent) is permitted.
- Confirmed presence of CNS tumor involvement.
- Evidence of other active malignancy requiring treatment.
We found this trial at
13
sites
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Emory University School of Medicine Emory University School of Medicine has 2,359 full- and part-time...
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University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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University of Chicago Medical Center The University of Chicago Medicine has been at the forefront...
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The University of California, San Diego UC San Diego is an academic powerhouse and economic...
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Columbia University Medical Center Situated on a 20-acre campus in Northern Manhattan and accounting for...
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