Spine Quantitative Computed Tomography (QCT)
| Status: | Completed |
|---|---|
| Conditions: | Arthritis, Arthritis, Osteoporosis |
| Therapuetic Areas: | Rheumatology |
| Healthy: | No |
| Age Range: | 5 - 21 |
| Updated: | 10/5/2017 |
| Start Date: | April 2008 |
| End Date: | June 2017 |
Spine Quantitative Computed Tomography (QCT) for the Assessment of Osteoporosis on Children
The purpose of this study is to compare healthy children to children who have a chronic
illness called Juvenile Idiopathic Arthritis (JIA). JIA is a childhood disease that causes
swollen joints that are often stiff and painful. JIA affects about 1 in 1,000 children age 16
and younger.
illness called Juvenile Idiopathic Arthritis (JIA). JIA is a childhood disease that causes
swollen joints that are often stiff and painful. JIA affects about 1 in 1,000 children age 16
and younger.
Children with chronic illnesses are at risk for bone fragility due to inflammation,
glucocorticoid therapy, physical activity limitation, malnutrition, and pubertal delay. The
impact of low bone mass during childhood may be immediate, resulting in childhood fractures,
or delayed, due to suboptimal peak bone mass attainment.
glucocorticoid therapy, physical activity limitation, malnutrition, and pubertal delay. The
impact of low bone mass during childhood may be immediate, resulting in childhood fractures,
or delayed, due to suboptimal peak bone mass attainment.
Inclusion Criteria:
- for JIA patients: subjects age 5-21 Drawn from Dr. Burnham's prospective cohort study
of bone health in 101 children with arthritis.
- for Control patients: subjects age 5-21 Controls will be a 50% male/female
Exclusion Criteria:
- for JIA patients: Subjects with JIA will be excluded if they have conditions or drug
exposure unrelated to JIA and known to impact growth or bone health.
- for Control patients: Chronic disease or syndrome known to affect growth or bone
health, prematurity (<37 weeks gestation), or use of any medication known to affect
growth.
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