High Water Intake to Slow Progression of Polycystic Kidney Disease
| Status: | Completed |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease, Nephrology |
| Therapuetic Areas: | Nephrology / Urology |
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 4/21/2016 |
| Start Date: | November 2008 |
| End Date: | May 2009 |
The Effect of Water Loading on Urinary Biomarkers
Polycystic kidney disease (PKD) is a genetic disease that occurs in 1 in 500 individuals and
leads to kidney failure in half of all affected. Currently, no treatments exist for PKD.
PKD-affected kidney cells divide and multiply inappropriately, and form fluid-filled sacs
called cysts. Kidney cysts continue to grow throughout life, destroying normal kidney
tissue, leading to kidney failure. Based on evidence from basic science research it is
believed that drinking high amounts of water can slow the abnormal cysts growth. This study
aims to look at changes in urine composition with high water intake in PKD-affected persons
compared to healthy individuals.
leads to kidney failure in half of all affected. Currently, no treatments exist for PKD.
PKD-affected kidney cells divide and multiply inappropriately, and form fluid-filled sacs
called cysts. Kidney cysts continue to grow throughout life, destroying normal kidney
tissue, leading to kidney failure. Based on evidence from basic science research it is
believed that drinking high amounts of water can slow the abnormal cysts growth. This study
aims to look at changes in urine composition with high water intake in PKD-affected persons
compared to healthy individuals.
Inclusion Criteria:
- Clinical diagnosis of Autosomal Dominant Polycystic Kidney Disease by history,
ultrasound, CT or MRI
- Healthy subjects without a diagnosis of Polycystic Kidney Disease by history,
ultrasound, CT or MRI
- Ages between 18 and 65
- Healthy subjects (without Polycystic Kidney Disease) must have an estimated
glomerular filtration rate (eGFR by the MDRD equation) > 60 ml/min/1.73 m2 with no
history of kidney disease
Exclusion Criteria:
- Women who are pregnant or nursing
- Active dependency on drugs or alcohol
- Diagnosis of syndrome of inappropriate antidiuresis
- Currently taking a vasopressin agonist or antagonist
- Blood sodium level less than < 135 mEq/L
- For healthy participants, estimated glomerular filtration rate (level of kidney
function) less than < 60 ml/min/1.73 m2
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New York University Langone Medical Center NYU NYU Langone Medical Center, a world-class, patient-centered, integrated,...
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