Optimizing Photodynamic Therapy of Cutaneous Neoplastic Diseases Via Structured Illumination and Real-time Dosimetry.
| Status: | Completed |
|---|---|
| Conditions: | Skin Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | October 2008 |
| End Date: | September 2012 |
Non-contact Imaging Device (Camera) Can Help Improve Treatment for Patients With Basal Cell Carcinoma.
The purpose of this study is to evaluate native tissue optical properties and
photosensitizer optical properties in vivo with a novel, non-contact optical imaging device
call Modulated Imaging to help optimize the laser exposure in future photodynamic treatment
for patients with skin cancer.
Photodynamic therapy involves the administration of a tumor-localizing photosensitizing
agent that, when illuminated with the proper wavelength of light, can result in
photochemical processes that cause irreversible damage to tumor tissues. Photodynamic
therapy is non-invasive and has been shown to be effective in the treatment of skin cancer
while producing excellent aesthetic appearance and psychological well-being in patients that
normally would require invasive excisions.
photosensitizer optical properties in vivo with a novel, non-contact optical imaging device
call Modulated Imaging to help optimize the laser exposure in future photodynamic treatment
for patients with skin cancer.
Photodynamic therapy involves the administration of a tumor-localizing photosensitizing
agent that, when illuminated with the proper wavelength of light, can result in
photochemical processes that cause irreversible damage to tumor tissues. Photodynamic
therapy is non-invasive and has been shown to be effective in the treatment of skin cancer
while producing excellent aesthetic appearance and psychological well-being in patients that
normally would require invasive excisions.
The current standard of care for skin cancer is excision, curettage and electrodesiccation
and/or cryosurgery.
The Modulated Imaging can measure tissue optical properties that effect the Photodynamic
therapy treatment process can show spectral absorption and scattering coefficients, oxy- and
deoxy-hemoglobin, water, melanin and use that information to provide customized laser light
treatment.
The researchers can use an imaging system that can characterize the tissue and
photosensitizer optical properties and use that information to drive a treatment light
projection system that can spatially optimize the light irradiance for personalized
treatment, thus improving outcomes.
and/or cryosurgery.
The Modulated Imaging can measure tissue optical properties that effect the Photodynamic
therapy treatment process can show spectral absorption and scattering coefficients, oxy- and
deoxy-hemoglobin, water, melanin and use that information to provide customized laser light
treatment.
The researchers can use an imaging system that can characterize the tissue and
photosensitizer optical properties and use that information to drive a treatment light
projection system that can spatially optimize the light irradiance for personalized
treatment, thus improving outcomes.
Inclusion Criteria:
- Age > 18 years
- Biopsy proven diagnosis of a basal cell carcinoma in a non-facial area
Exclusion Criteria:
- Age < 18 years
- Pregnancy
- Breast feeding.
- photosensitivity
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