Immunologic Abnormalities, Chronic Inflammation and Oxidative Stress in Chronic Kidney Disease
| Status: | Completed |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease |
| Therapuetic Areas: | Nephrology / Urology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/21/2016 |
| Start Date: | August 2008 |
| End Date: | March 2012 |
The common causes of mortality are late stages of chronic kidney disease, cardiovascular
disease and infections, are associated with abnormalities of the immune system, an
underlying state of chronic inflammation and oxidative stress. These processes have not been
carefully described in the chronic kidney disease population. The researcher can use Diffuse
Optical Spectroscopy to determine the immune system in individuals with chronic kidney
disease and describe the association with chronic inflammation and oxidative stress in that
population.
disease and infections, are associated with abnormalities of the immune system, an
underlying state of chronic inflammation and oxidative stress. These processes have not been
carefully described in the chronic kidney disease population. The researcher can use Diffuse
Optical Spectroscopy to determine the immune system in individuals with chronic kidney
disease and describe the association with chronic inflammation and oxidative stress in that
population.
The Diffuse Optical Spectroscopy can measure the absolute concentrations of reduced and
oxygenated hemoglobins,cardiac output, mean arterial pressure, blood loss,blood hemoglobin
concentration, water and lipid concentrations of the tissue.
The researchers can use Diffuse Optical Spectroscopy to monitor volume changes during the
hemodialysis treatment and to correlate the changes in volume and blood pressure with the
measures of oxidative stress and inflammation used in this study. The researchers can use
Diffuse Optical Spectroscopy data to compare to laboratory parameters routinely measured to
clinical parameters such as cause of chronic kidney disease, blood pressure and
dialysis-related parameters.
oxygenated hemoglobins,cardiac output, mean arterial pressure, blood loss,blood hemoglobin
concentration, water and lipid concentrations of the tissue.
The researchers can use Diffuse Optical Spectroscopy to monitor volume changes during the
hemodialysis treatment and to correlate the changes in volume and blood pressure with the
measures of oxidative stress and inflammation used in this study. The researchers can use
Diffuse Optical Spectroscopy data to compare to laboratory parameters routinely measured to
clinical parameters such as cause of chronic kidney disease, blood pressure and
dialysis-related parameters.
Inclusion Criteria:
- 18 years and older with chronic kidney disease undergoing hemodialysis have been
treated with hemodialysis for at least 3 months
- 18 years and older for control
Exclusion Criteria:
- acute kidney disease
We found this trial at
3
sites
Click here to add this to my saved trials
Click here to add this to my saved trials
Click here to add this to my saved trials