A Study to Evaluate Ocrelizumab in Combination With Methotrexate Compared With Infliximab Plus Methotrexate in Patients With Active Rheumatoid Arthritis Currently Responding Inadequately to Etanercept or Adalimumab



Status:Terminated
Conditions:Arthritis, Rheumatoid Arthritis
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:March 2009
End Date:November 2012

Use our guide to learn which trials are right for you!

A PHASE II RANDOMIZED, DOUBLE-BLIND, PARALLEL GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF OCRELIZUMAB IN COMBINATION WITH METHOTREXATE, COMPARED TO INFLIXIMAB PLUS METHOTREXATE IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS CURRENTLY RESPONDING INADEQUATELY TO ETANERCEPT OR ADALIMUMAB

This is a Phase II, randomized, active-controlled, double-blind, double-dummy,
parallel-group, multicenter study in the United States enrolling patients with active RA.
The study will enroll approximately 290 patients at approximately 130 sites.


Inclusion Criteria:

- Age >= 18 years

- Current treatment for RA on an outpatient basis

- Active disease

- Currently receiving 50 mg etanercept subcutaneously (SC) every week or 40 mg
adalimumab SC every other week.

- Considered by Investigator to be a primary non-responder to their first anti-TNFα
treatment for efficacy reasons

Exclusion Criteria:

- Rheumatic autoimmune disease other than RA, or significant systemic involvement
secondary to RA

- History of, or current, inflammatory joint disease other than RA (e.g., gout,
reactive arthritis, psoriatic arthritis, seronegative spondyloarthropathy, Lyme
disease) or other systemic autoimmune disorder (e.g., systemic lupus erythematosus,
inflammatory bowel disease, scleroderma, inflammatory myopathy, mixed connective
tissue disease or other overlap syndrome)

- Previous treatment with a any biologic therapy for RA (including investigational
products with the exception of etanercept or adalimumab

- Treatment with more than one prior anti-TNFα therapy
We found this trial at
110
sites
506
mi
from 43215
Jonesboro, AR
Click here to add this to my saved trials
513
mi
from 43215
Albany, NY
Click here to add this to my saved trials
400
mi
from 43215
Allentown, PA
Click here to add this to my saved trials
1078
mi
from 43215
Amarillo, TX
Click here to add this to my saved trials
436
mi
from 43215
Atlanta, GA
Click here to add this to my saved trials
981
mi
from 43215
Aventura, FL
Click here to add this to my saved trials
343
mi
from 43215
Belmont, NC
Click here to add this to my saved trials
405
mi
from 43215
Bethlehem, PA
Click here to add this to my saved trials
1344
mi
from 43215
Billings, MT
Click here to add this to my saved trials
398
mi
from 43215
Binghamton, NY
Click here to add this to my saved trials
492
mi
from 43215
Birmingham, AL
Click here to add this to my saved trials
955
mi
from 43215
Boca Raton, FL
Click here to add this to my saved trials
1714
mi
from 43215
Boise, ID
Click here to add this to my saved trials
276
mi
from 43215
Bowling Green, KY
Click here to add this to my saved trials
522
mi
from 43215
Bridgeport, CT
Click here to add this to my saved trials
478
mi
from 43215
Brooklyn, NY
Click here to add this to my saved trials
471
mi
from 43215
Cedar Rapids, IA
Click here to add this to my saved trials
Charlotte, North Carolina 28207
350
mi
from 43215
Charlotte, NC
Click here to add this to my saved trials
98
mi
from 43215
Cincinnati, OH
Click here to add this to my saved trials
470
mi
from 43215
Clifton, NJ
Click here to add this to my saved trials
Colorado Springs, Colorado 80910
1161
mi
from 43215
Colorado Springs, CO
Click here to add this to my saved trials
426
mi
from 43215
Columbia, SC
Click here to add this to my saved trials
6
mi
from 43215
Columbus, OH
Click here to add this to my saved trials
910
mi
from 43215
Dallas, TX
Click here to add this to my saved trials
430
mi
from 43215
Decatur, GA
Click here to add this to my saved trials
1162
mi
from 43215
Denver, CO
Click here to add this to my saved trials
654
mi
from 43215
Duluth, MN
Click here to add this to my saved trials
825
mi
from 43215
Dunedin, FL
Click here to add this to my saved trials
354
mi
from 43215
Durham, NC
Click here to add this to my saved trials
212
mi
from 43215
Erie, PA
Click here to add this to my saved trials
282
mi
from 43215
Evanston, IL
Click here to add this to my saved trials
280
mi
from 43215
Evansville, IN
Click here to add this to my saved trials
213
mi
from 43215
Flint, MI
Click here to add this to my saved trials
398
mi
from 43215
Florissant, MO
Click here to add this to my saved trials
660
mi
from 43215
Flowood, MS
Click here to add this to my saved trials
937
mi
from 43215
Fort Worth, TX
Click here to add this to my saved trials
300
mi
from 43215
Frederick, MD
Click here to add this to my saved trials
1958
mi
from 43215
Fullerton, CA
Click here to add this to my saved trials
393
mi
from 43215
Gainesville, GA
Click here to add this to my saved trials
288
mi
from 43215
Glenview, IL
Click here to add this to my saved trials
Greenville, North Carolina 27834
429
mi
from 43215
Greenville, NC
Click here to add this to my saved trials
Greenville, South Carolina 29605
358
mi
from 43215
Greenville, SC
Click here to add this to my saved trials
282
mi
from 43215
Hagerstown, MD
Click here to add this to my saved trials
351
mi
from 43215
Hixson, TN
Click here to add this to my saved trials
991
mi
from 43215
Houston, TX
Click here to add this to my saved trials
410
mi
from 43215
Huntsville, AL
Click here to add this to my saved trials
1508
mi
from 43215
Idaho Falls, ID
Click here to add this to my saved trials
660
mi
from 43215
Jackson, MS
Click here to add this to my saved trials
431
mi
from 43215
Jackson, TN
Click here to add this to my saved trials
916
mi
from 43215
Jupiter, FL
Click here to add this to my saved trials
206
mi
from 43215
Kalamazoo, MI
Click here to add this to my saved trials
1640
mi
from 43215
Kalispell, MT
Click here to add this to my saved trials
620
mi
from 43215
Kansas City, KS
Click here to add this to my saved trials
206
mi
from 43215
Lansing, MI
Click here to add this to my saved trials
609
mi
from 43215
Lebanon, NH
Click here to add this to my saved trials
622
mi
from 43215
Little Rock, AR
Click here to add this to my saved trials
1975
mi
from 43215
Long Beach, CA
Click here to add this to my saved trials
493
mi
from 43215
Macon, GA
Click here to add this to my saved trials
425
mi
from 43215
Marietta, GA
Click here to add this to my saved trials
508
mi
from 43215
Memphis, TN
Click here to add this to my saved trials
902
mi
from 43215
Mesquite, TX
Click here to add this to my saved trials
116
mi
from 43215
Middleburg Heights, OH
Click here to add this to my saved trials
404
mi
from 43215
Moline, IL
Click here to add this to my saved trials
286
mi
from 43215
Morton Grove, IL
Click here to add this to my saved trials
1930
mi
from 43215
Murrieta, CA
Click here to add this to my saved trials
Myrtle Beach, South Carolina 29572
487
mi
from 43215
Myrtle Beach, SC
Click here to add this to my saved trials
331
mi
from 43215
Nashville, TN
Click here to add this to my saved trials
481
mi
from 43215
New York, NY
Click here to add this to my saved trials
422
mi
from 43215
Norfolk, VA
Click here to add this to my saved trials
849
mi
from 43215
Oklahoma City, OK
Click here to add this to my saved trials
280
mi
from 43215
Olean, NY
Click here to add this to my saved trials
682
mi
from 43215
Omaha, NE
Click here to add this to my saved trials
?
mi
from 43215
Orchard Park, NY
Click here to add this to my saved trials
792
mi
from 43215
Orlando, FL
Click here to add this to my saved trials
821
mi
from 43215
Palm Habor, FL
Click here to add this to my saved trials
1653
mi
from 43215
Paradise Valley, AZ
Click here to add this to my saved trials
416
mi
from 43215
Philadelphia, PA
Click here to add this to my saved trials
704
mi
from 43215
Portland, ME
Click here to add this to my saved trials
2026
mi
from 43215
Portland, OR
Click here to add this to my saved trials
311
mi
from 43215
Racine, WI
Click here to add this to my saved trials
1080
mi
from 43215
Rapid City, IA
Click here to add this to my saved trials
1938
mi
from 43215
Reno, NV
Click here to add this to my saved trials
351
mi
from 43215
Rockford, IL
Click here to add this to my saved trials
411
mi
from 43215
Rome, GA
Click here to add this to my saved trials
2039
mi
from 43215
Sacramento, CA
Click here to add this to my saved trials
394
mi
from 43215
Saint Louis, MO
Click here to add this to my saved trials
1144
mi
from 43215
San Antonio, TX
Click here to add this to my saved trials
1951
mi
from 43215
San Diego, CA
Click here to add this to my saved trials
1985
mi
from 43215
Santa Monica, CA
Click here to add this to my saved trials
874
mi
from 43215
Sarasota, FL
Click here to add this to my saved trials
2005
mi
from 43215
Seattle, WA
Click here to add this to my saved trials
789
mi
from 43215
Shreveport, LA
Click here to add this to my saved trials
519
mi
from 43215
Smithtown, NY
Click here to add this to my saved trials
997
mi
from 43215
South Miami, FL
Click here to add this to my saved trials
1778
mi
from 43215
Spokane, WA
Click here to add this to my saved trials
353
mi
from 43215
Springfield, IL
Click here to add this to my saved trials
St. Claire Shores, Michigan 48081
175
mi
from 43215
St. Claire Shores, MI
Click here to add this to my saved trials
414
mi
from 43215
Syracuse, NY
Click here to add this to my saved trials
2012
mi
from 43215
Tacoma, WA
Click here to add this to my saved trials
831
mi
from 43215
Tampa, FL
Click here to add this to my saved trials
1983
mi
from 43215
Torrance, CA
Click here to add this to my saved trials