A Study to Evaluate Ocrelizumab in Combination With Methotrexate Compared With Infliximab Plus Methotrexate in Patients With Active Rheumatoid Arthritis Currently Responding Inadequately to Etanercept or Adalimumab



Status:Terminated
Conditions:Arthritis, Rheumatoid Arthritis
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:18 - Any
Updated:4/21/2016
Start Date:March 2009
End Date:November 2012

Use our guide to learn which trials are right for you!

A PHASE II RANDOMIZED, DOUBLE-BLIND, PARALLEL GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF OCRELIZUMAB IN COMBINATION WITH METHOTREXATE, COMPARED TO INFLIXIMAB PLUS METHOTREXATE IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS CURRENTLY RESPONDING INADEQUATELY TO ETANERCEPT OR ADALIMUMAB

This is a Phase II, randomized, active-controlled, double-blind, double-dummy,
parallel-group, multicenter study in the United States enrolling patients with active RA.
The study will enroll approximately 290 patients at approximately 130 sites.


Inclusion Criteria:

- Age >= 18 years

- Current treatment for RA on an outpatient basis

- Active disease

- Currently receiving 50 mg etanercept subcutaneously (SC) every week or 40 mg
adalimumab SC every other week.

- Considered by Investigator to be a primary non-responder to their first anti-TNFα
treatment for efficacy reasons

Exclusion Criteria:

- Rheumatic autoimmune disease other than RA, or significant systemic involvement
secondary to RA

- History of, or current, inflammatory joint disease other than RA (e.g., gout,
reactive arthritis, psoriatic arthritis, seronegative spondyloarthropathy, Lyme
disease) or other systemic autoimmune disorder (e.g., systemic lupus erythematosus,
inflammatory bowel disease, scleroderma, inflammatory myopathy, mixed connective
tissue disease or other overlap syndrome)

- Previous treatment with a any biologic therapy for RA (including investigational
products with the exception of etanercept or adalimumab

- Treatment with more than one prior anti-TNFα therapy
We found this trial at
110
sites
1306
mi
from
Albany, NY
Click here to add this to my saved trials
1209
mi
from
Allentown, PA
Click here to add this to my saved trials
283
mi
from
Amarillo, TX
Click here to add this to my saved trials
801
mi
from
Atlanta, GA
Click here to add this to my saved trials
1314
mi
from
Aventura, FL
Click here to add this to my saved trials
946
mi
from
Belmont, NC
Click here to add this to my saved trials
1215
mi
from
Bethlehem, PA
Click here to add this to my saved trials
780
mi
from
Billings, MT
Click here to add this to my saved trials
1195
mi
from
Binghamton, NY
Click here to add this to my saved trials
683
mi
from
Birmingham, AL
Click here to add this to my saved trials
1299
mi
from
Boca Raton, FL
Click here to add this to my saved trials
1039
mi
from
Boise, ID
Click here to add this to my saved trials
625
mi
from
Bowling Green, KY
Click here to add this to my saved trials
1330
mi
from
Bridgeport, CT
Click here to add this to my saved trials
1287
mi
from
Brooklyn, NY
Click here to add this to my saved trials
437
mi
from
Cedar Rapids, IA
Click here to add this to my saved trials
Charlotte, North Carolina 28207
959
mi
from
Charlotte, NC
Click here to add this to my saved trials
726
mi
from
Cincinnati, OH
Click here to add this to my saved trials
1279
mi
from
Clifton, NJ
Click here to add this to my saved trials
Colorado Springs, Colorado 80910
383
mi
from
Colorado Springs, CO
Click here to add this to my saved trials
972
mi
from
Columbia, SC
Click here to add this to my saved trials
810
mi
from
Columbus, OH
Click here to add this to my saved trials
349
mi
from
Dallas, TX
Click here to add this to my saved trials
805
mi
from
Decatur, GA
Click here to add this to my saved trials
409
mi
from
Denver, CO
Click here to add this to my saved trials
689
mi
from
Duluth, MN
Click here to add this to my saved trials
1099
mi
from
Dunedin, FL
Click here to add this to my saved trials
1051
mi
from
Durham, NC
Click here to add this to my saved trials
983
mi
from
Erie, PA
Click here to add this to my saved trials
613
mi
from
Evanston, IL
Click here to add this to my saved trials
559
mi
from
Evansville, IN
Click here to add this to my saved trials
822
mi
from
Flint, MI
Click here to add this to my saved trials
412
mi
from
Florissant, MO
Click here to add this to my saved trials
574
mi
from
Flowood, MS
Click here to add this to my saved trials
346
mi
from
Fort Worth, TX
Click here to add this to my saved trials
1105
mi
from
Frederick, MD
Click here to add this to my saved trials
1153
mi
from
Fullerton, CA
Click here to add this to my saved trials
815
mi
from
Gainesville, GA
Click here to add this to my saved trials
608
mi
from
Glenview, IL
Click here to add this to my saved trials
Greenville, North Carolina 27834
1139
mi
from
Greenville, NC
Click here to add this to my saved trials
Greenville, South Carolina 29605
882
mi
from
Greenville, SC
Click here to add this to my saved trials
1089
mi
from
Hagerstown, MD
Click here to add this to my saved trials
724
mi
from
Hixson, TN
Click here to add this to my saved trials
569
mi
from
Houston, TX
Click here to add this to my saved trials
660
mi
from
Huntsville, AL
Click here to add this to my saved trials
843
mi
from
Idaho Falls, ID
Click here to add this to my saved trials
571
mi
from
Jackson, MS
Click here to add this to my saved trials
518
mi
from
Jackson, TN
Click here to add this to my saved trials
415
mi
from
Jonesboro, AR
Click here to add this to my saved trials
1271
mi
from
Jupiter, FL
Click here to add this to my saved trials
721
mi
from
Kalamazoo, MI
Click here to add this to my saved trials
1098
mi
from
Kalispell, MT
Click here to add this to my saved trials
196
mi
from
Kansas City, KS
Click here to add this to my saved trials
779
mi
from
Lansing, MI
Click here to add this to my saved trials
1393
mi
from
Lebanon, NH
Click here to add this to my saved trials
372
mi
from
Little Rock, AR
Click here to add this to my saved trials
1171
mi
from
Long Beach, CA
Click here to add this to my saved trials
871
mi
from
Macon, GA
Click here to add this to my saved trials
788
mi
from
Marietta, GA
Click here to add this to my saved trials
467
mi
from
Memphis, TN
Click here to add this to my saved trials
350
mi
from
Mesquite, TX
Click here to add this to my saved trials
887
mi
from
Middleburg Heights, OH
Click here to add this to my saved trials
467
mi
from
Moline, IL
Click here to add this to my saved trials
608
mi
from
Morton Grove, IL
Click here to add this to my saved trials
1124
mi
from
Murrieta, CA
Click here to add this to my saved trials
Myrtle Beach, South Carolina 29572
1099
mi
from
Myrtle Beach, SC
Click here to add this to my saved trials
618
mi
from
Nashville, TN
Click here to add this to my saved trials
1290
mi
from
New York, NY
Click here to add this to my saved trials
1181
mi
from
Norfolk, VA
Click here to add this to my saved trials
158
mi
from
Oklahoma City, OK
Click here to add this to my saved trials
1067
mi
from
Olean, NY
Click here to add this to my saved trials
262
mi
from
Omaha, NE
Click here to add this to my saved trials
?
mi
from
Orchard Park, NY
Click here to add this to my saved trials
1139
mi
from
Orlando, FL
Click here to add this to my saved trials
1099
mi
from
Palm Habor, FL
Click here to add this to my saved trials
844
mi
from
Paradise Valley, AZ
Click here to add this to my saved trials
1225
mi
from
Philadelphia, PA
Click here to add this to my saved trials
1492
mi
from
Portland, ME
Click here to add this to my saved trials
1383
mi
from
Portland, OR
Click here to add this to my saved trials
630
mi
from
Racine, WI
Click here to add this to my saved trials
521
mi
from
Rapid City, IA
Click here to add this to my saved trials
1188
mi
from
Reno, NV
Click here to add this to my saved trials
560
mi
from
Rockford, IL
Click here to add this to my saved trials
742
mi
from
Rome, GA
Click here to add this to my saved trials
1278
mi
from
Sacramento, CA
Click here to add this to my saved trials
418
mi
from
Saint Louis, MO
Click here to add this to my saved trials
583
mi
from
San Antonio, TX
Click here to add this to my saved trials
1143
mi
from
San Diego, CA
Click here to add this to my saved trials
1181
mi
from
Santa Monica, CA
Click here to add this to my saved trials
1143
mi
from
Sarasota, FL
Click here to add this to my saved trials
1410
mi
from
Seattle, WA
Click here to add this to my saved trials
429
mi
from
Shreveport, LA
Click here to add this to my saved trials
1328
mi
from
Smithtown, NY
Click here to add this to my saved trials
1320
mi
from
South Miami, FL
Click here to add this to my saved trials
1201
mi
from
Spokane, WA
Click here to add this to my saved trials
460
mi
from
Springfield, IL
Click here to add this to my saved trials
St. Claire Shores, Michigan 48081
852
mi
from
St. Claire Shores, MI
Click here to add this to my saved trials
1193
mi
from
Syracuse, NY
Click here to add this to my saved trials
1407
mi
from
Tacoma, WA
Click here to add this to my saved trials
1117
mi
from
Tampa, FL
Click here to add this to my saved trials
1178
mi
from
Torrance, CA
Click here to add this to my saved trials