Feasibility Study of Prostate Tumor Localization for Focal Cryoablation of Prostate Carcinoma
| Status: | Terminated |
|---|---|
| Conditions: | Prostate Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 20 - 85 |
| Updated: | 11/2/2018 |
| Start Date: | January 2009 |
| End Date: | February 2014 |
The purpose of the present study is to find out if MRI techniques examining (1) the motion of
water molecules in the prostate (diffusion sensitive MRI), (2) the difference in blood flow
to the prostate (dynamic contrast enhanced MRI), and (3) differences in chemical composition
of the prostate (MR spectroscopy), can be used to detect prostate cancer early and
non-invasively. Localization of the cancer within the prostate would be of particular
importance in focal cryoablation of prostate carcinoma which we hope to improve as a result
of this project.
Additional aim of the study is to correlate expression of genes believed to pay a role in
prostate cancer with MRI findings.
water molecules in the prostate (diffusion sensitive MRI), (2) the difference in blood flow
to the prostate (dynamic contrast enhanced MRI), and (3) differences in chemical composition
of the prostate (MR spectroscopy), can be used to detect prostate cancer early and
non-invasively. Localization of the cancer within the prostate would be of particular
importance in focal cryoablation of prostate carcinoma which we hope to improve as a result
of this project.
Additional aim of the study is to correlate expression of genes believed to pay a role in
prostate cancer with MRI findings.
Radical prostatectomy patients will undergo an MRI prior to their scheduled surgery. Ex vivo
imaging will be done on prostates once removed. Results from the final pathology with be
compared with results of imaging to determine the accuracy of the image analysis in cancer
localization and staging.
Brachytherapy patients will undergo an MRI prior to their scheduled procedure. Two areas of
suspected cancer and two areas without suspected cancer will be prospectively identified
based on the MRI imaging. At the time of brachytherapy, transrectal needle biopsies will be
obtained from the previously identified areas. The needle cores will be reviewed by study
pathologist to determine the accuracy of the image analysis in cancer localization and
staging.
imaging will be done on prostates once removed. Results from the final pathology with be
compared with results of imaging to determine the accuracy of the image analysis in cancer
localization and staging.
Brachytherapy patients will undergo an MRI prior to their scheduled procedure. Two areas of
suspected cancer and two areas without suspected cancer will be prospectively identified
based on the MRI imaging. At the time of brachytherapy, transrectal needle biopsies will be
obtained from the previously identified areas. The needle cores will be reviewed by study
pathologist to determine the accuracy of the image analysis in cancer localization and
staging.
Inclusion Criteria:
- patients who have been diagnosed with prostate cancer and are scheduled for radical
prostatectomy or for brachytherapy
- patients who have not received any preoperative treatment for their diagnosis of
prostate cancer
Exclusion Criteria:
- patients with implants that are electronically, magnetically, or mechanically active
- patients with intracranial aneurysm clips
- patients who have undergone cosmetic eyelid surgery
- patients with history of pheochromocytoma, insulinoma and acute glaucoma
- patients with estimated glomerular filtration rate (eGFR) less than 60 ml/min/1.73m2
We found this trial at
1
site
660 S Euclid Ave
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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