Role of CXCR2 Ligands/CXCR2 Biological Axis in Pancreatic Cancer
| Status: | Completed |
|---|---|
| Conditions: | Cancer, Cancer, Gastrointestinal, Gastrointestinal, Pancreatic Cancer |
| Therapuetic Areas: | Gastroenterology, Oncology |
| Healthy: | No |
| Age Range: | 18 - 90 |
| Updated: | 4/21/2016 |
| Start Date: | May 2007 |
| End Date: | November 2011 |
The investigators hypothesize that the CXCR2 ligands/CXCR2 biological axis plays an
important role in promoting angiogenesis in PC; and that the genetic changes and the
microenvironment of the tumor regulate the expression of CXCR2 ligands/CXCR2 in PC in order
to potentiate their angiogenic phenotype. A corollary of this hypothesis is that the cell
surface receptors (CXCR2) and the intracellular signaling pathways that mediate the
angiogenic responses induced by ELR+ CXC-chemokines are potential targets for novel
therapeutic interventions in PC.
important role in promoting angiogenesis in PC; and that the genetic changes and the
microenvironment of the tumor regulate the expression of CXCR2 ligands/CXCR2 in PC in order
to potentiate their angiogenic phenotype. A corollary of this hypothesis is that the cell
surface receptors (CXCR2) and the intracellular signaling pathways that mediate the
angiogenic responses induced by ELR+ CXC-chemokines are potential targets for novel
therapeutic interventions in PC.
Inclusion Criteria:
- Normal subjects - No documented clinical history of pancreatic diseases supported by
at least 1 negative imaging test. (EUS, Ct scan or MRI)
- Chronic pancreatitis - Documented diagnosis of moderate to advanced chronic supported
bpancreatitisy at least 1 positive imaging test. (EUS, Ct scan or MRI)
- Pancreatic Cancer - Documented tissue diagnosis (or clinical suspicion) of Pancreatic
Cancer.
Exclusion Criteria:
- Exclusion criteria will include age younger than 18 yrs, pregnancy, previous
pancreatic or gastric resection, and inability to tolerate routine endoscopy with
conscious sedation
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