Dose Finding Study of HP802-247 in Venous Leg Ulcers

Inclusion Criteria:

- Provide informed consent.

- Willing to comply with protocol instructions, including allowing all study
assessments.

- Have a venous leg ulcer (venous etiology)between the knee and ankle, at or above the
malleolus.

- Venous insufficiency confirmed by duplex Doppler ultrasound examination for valvular
or venous incompetence.

- Target ulcer duration greater than or equal to 6 weeks but less than or equal to 24
months.

Exclusion Criteria:

- Women who are pregnant or lactating

- Therapy with another investigational agent within thirty (30) days of Screening, or
during the study.

- A target ulcer of non-venous etiologies.

- Refusal of or inability to tolerate compression therapy.

- Therapy of the target ulcer with tissue-engineered cell-based skin equivalents within
30 days preceding the Screening Visit.

- Therapy of the target ulcer with topical growth factors within 1 week preceding the
Screening Visit.