Effect of Daily Low Dose Aspirin on Exhaled Inflammatory Mediators in Normal Subjects
| Status: | Completed |
|---|---|
| Conditions: | Healthy Studies |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 95 |
| Updated: | 4/21/2016 |
| Start Date: | May 2009 |
| End Date: | August 2009 |
Hypothesis: Low dose aspirin does not change exhaled inflammatory breath mediators in normal
subjects.
subjects.
Aim:
1. To study the effect of low dose aspirin on exhaled breath inflammatory mediators
2. To compare the change to that seen in diseased states such as asthma and
Lymphangioleiomyomatosis (LAM)
We will interview healthy volunteers to confirm that they do not have any major underlying
medical conditions such as heart disease, diabetes, stroke and bleeding disorders. We will
collect breath condensate before and after two weeks of low dose over the counter enteric
coated aspirin 81 mg/day therapy. Side effects are extremely rare at this dose, but include
bleeding, heart burn and allergic reaction.
1. To study the effect of low dose aspirin on exhaled breath inflammatory mediators
2. To compare the change to that seen in diseased states such as asthma and
Lymphangioleiomyomatosis (LAM)
We will interview healthy volunteers to confirm that they do not have any major underlying
medical conditions such as heart disease, diabetes, stroke and bleeding disorders. We will
collect breath condensate before and after two weeks of low dose over the counter enteric
coated aspirin 81 mg/day therapy. Side effects are extremely rare at this dose, but include
bleeding, heart burn and allergic reaction.
Inclusion Criteria:
- healthy adults
Exclusion Criteria:
- any underlying major medical conditions such as heart disease, hypertension, stroke,
diabetes, bleeding disorders
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