Deep Brain Stimulation of the Subthalamic Nucleus (STN) and Cognitive Control
| Status: | Completed |
|---|---|
| Conditions: | Parkinsons Disease |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 4/21/2016 |
| Start Date: | March 2006 |
| End Date: | December 2013 |
Deep Brain Stimulation of the STN and Cognitive Control: A Pilot Study
In this study, the investigators will follow patients who have had stimulators implanted, at
their usual clinic follow-up appointments 3, 6, 9 and 12 months after surgery. It is typical
at these appointments for patients to be off medication and for the stimulators to be turned
off to observe disease progress and test stimulator effectiveness. Also as part of standard
clinical practice, stimulator settings are adjusted for optimal benefit to motor symptoms.
Only patients who already have implants will be invited to participate in this study, and no
changes to stimulator settings are made for the purposes of this study. Stimulator settings
are changed based on clinical evaluation of motor symptoms, and this study has no bearing on
how stimulators will be set nor how often they will be set.
their usual clinic follow-up appointments 3, 6, 9 and 12 months after surgery. It is typical
at these appointments for patients to be off medication and for the stimulators to be turned
off to observe disease progress and test stimulator effectiveness. Also as part of standard
clinical practice, stimulator settings are adjusted for optimal benefit to motor symptoms.
Only patients who already have implants will be invited to participate in this study, and no
changes to stimulator settings are made for the purposes of this study. Stimulator settings
are changed based on clinical evaluation of motor symptoms, and this study has no bearing on
how stimulators will be set nor how often they will be set.
Inclusion Criteria:
- Meet criteria for "definite" Parkinson's Disease (PD)
- STN stimulators on both sides (right and left)
- Surgery done at Washington University within 2 years
Exclusion Criteria:
- Significant visual deficits (e.g. double vision, untreated eyelid apraxia,
blepharospasm) Must be able to see screen
- Secondary Parkinsonism (drug-induced or other known etiologies)
- Brain injury or defect: history of serious head injury, stroke, encephalitis, defect
found on brain imaging
- Early severe dementia (within first year of onset) or on cholinesterase inhibitors
- Pre-surgical Mini Mental Status exam score < 24
- Significant current psychiatric diagnoses (such as depression or psychosis) or on
neuroleptics
We found this trial at
1
site
Click here to add this to my saved trials
