Dietary, Physiological, Genetic, and Behavioral Predictors of Health in a Young, Ethnically-Mixed Population
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 20 - 35 |
| Updated: | 3/23/2019 |
| Start Date: | June 2008 |
| End Date: | August 2023 |
Dietary intervention and other strategies to prevent unhealthy weight gain and the
development of obesity should be based on knowledge of dietary, physiological, genetic and
behavioral determinants and their contributing interactions. Identifying these determinants
is difficult because physiological susceptibility to specific dietary and behavioral factors
implicated in unhealthy weight gain differs between populations and individuals within the
populations. The research challenge is identifying specific determinants in a free-living,
adult population.
Understanding the interaction between diet and the underlying susceptibility factors such as
physiologic, genetic and epigenetic, and behavioral factors mandate an integrated approach.
This integrated approach should include understanding the interplay of physiological factors
(genetics, epigenetics, taste preferences, susceptibility to energy excess, etc.) and
behavioral factors (food cravings, restraint, disinhibition, physical activity) as each of
these domains is a potential driving force in energy expenditure, food preference, dietary
choices, and food intake.
Which of these factor(s) is most important? The investigators propose that by examining
dietary, physiological, genetic, and behavioral factors in an integrated fashion we will gain
insight into the obesity epidemic and identify the most important determinants of weight
gain. As a secondary aim, the investigators will identify a single parsimonious collection of
factors and develop strategies to mitigate the risks of developing obesity.
development of obesity should be based on knowledge of dietary, physiological, genetic and
behavioral determinants and their contributing interactions. Identifying these determinants
is difficult because physiological susceptibility to specific dietary and behavioral factors
implicated in unhealthy weight gain differs between populations and individuals within the
populations. The research challenge is identifying specific determinants in a free-living,
adult population.
Understanding the interaction between diet and the underlying susceptibility factors such as
physiologic, genetic and epigenetic, and behavioral factors mandate an integrated approach.
This integrated approach should include understanding the interplay of physiological factors
(genetics, epigenetics, taste preferences, susceptibility to energy excess, etc.) and
behavioral factors (food cravings, restraint, disinhibition, physical activity) as each of
these domains is a potential driving force in energy expenditure, food preference, dietary
choices, and food intake.
Which of these factor(s) is most important? The investigators propose that by examining
dietary, physiological, genetic, and behavioral factors in an integrated fashion we will gain
insight into the obesity epidemic and identify the most important determinants of weight
gain. As a secondary aim, the investigators will identify a single parsimonious collection of
factors and develop strategies to mitigate the risks of developing obesity.
This is a prospective, longitudinal, clinical study using an epidemiological approach. The
sample consists of 90 free-living participants aged 20-35 years. The participants will
undergo a series of assessments in the domains of diet, physiological factors, and behavioral
factors at baseline and every 12 months for 2 years.
OBJECTIVES
1. Identify dietary, physiological, genetic and behavioral determinants of unhealthy weight
gain in healthy, young, ethnically-mixed men and women.
2. Identify relationships between genetic measures of taste perception and the determinants
of unhealthy weight gain in the said population.
3. Identify relationships among the determinants of unhealthy weight gain that contribute
to an individual's susceptibility to obesity.
sample consists of 90 free-living participants aged 20-35 years. The participants will
undergo a series of assessments in the domains of diet, physiological factors, and behavioral
factors at baseline and every 12 months for 2 years.
OBJECTIVES
1. Identify dietary, physiological, genetic and behavioral determinants of unhealthy weight
gain in healthy, young, ethnically-mixed men and women.
2. Identify relationships between genetic measures of taste perception and the determinants
of unhealthy weight gain in the said population.
3. Identify relationships among the determinants of unhealthy weight gain that contribute
to an individual's susceptibility to obesity.
Inclusion Criteria:
- Inclusion criteria will be healthy men and women between the ages of 20-35, with BMI <
27.5 kg/m2, and fasting blood glucose < 126 mg/dl.
Exclusion Criteria:
- History of diabetes, history of obesity (BMI > 30).
- History of known inherited medical conditions that might influence future health
status.
- Current or planned medication usage that might influence future health status.
- Prior serious injuries/surgeries that might influence future health status.
- Women who are pregnant or breastfeeding (once enrolled, pregnancy will not cause
subjects to be terminated from the study).
- Women who are < 6 months postpartal, or women who have discontinued breastfeeding < 3
months prior to screening.
- History of cancer (including skin cancer) within 5 years.
- History or organ transplant.
- Previous diagnosis with HIV, Hepatitis B or C, or tuberculosis.
- Abuse of alcohol or illegal drugs.
- Abnormal EKG.
- Presence of pacemaker, defibrillator, or implanted metal.
- History of eating disorders and abnormal psychological scores for the screening
measures described under Psychological Assessment Measures in the Appendix. This
psychological screening will be conducted approximately two weeks prior to outpatient
testing.
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