Long-term Safety of Dasatinib in Patients With Chronic Myelogenous Leukemia or Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

Key Inclusion Criteria

- Signed written informed consent

- Received treatment in protocols CA180-005, CA180-006, CA180-013, CA180-015 or
CA180-017, or CA180-039

- Received clinical benefit with dasatinib or imatinib (study CA180017) in the opinion
of the Investigator

- Men and women, ages 18 and older

Key Exclusion Criteria

- A serious uncontrolled medical disorder or active infection that would impair the
ability of the patient to receive protocol therapy

- Dementia or altered mental status that would prohibit the understanding or rendering
of informed consent

- Patients currently taking drugs, including but not limited to quinidine,
procainamide, disopyramide, amiodarone, sotalol, ibutilide, dofetilide,
erythromycins, clarithromycin, chlorpromazine, haloperidol, mesoridazine,
thioridazine, pimozide, ziprasidone, cisapride, bepridil, droperidol, methadone,
arsenic, chloroquine, domperidone, halofantrine, levomethadyl, pentamidine,
sparfloxacin, and lidoflazine, which are generally accepted to have a risk of causing
Torsades de Pointes

- Patients taking medications known to be potent CYP3A4 inhibitors (ketoconazole,
ritonavir) or inducers (rifampin, efavirenz)