Study to Evaluate the Long-Term Safety of PA32540 in Subjects Who Are at Risk for Developing Aspirin-Associated Gastric Ulcers

PA32540 is proposed for the secondary prevention of cardio- and cerebrovascular events in
patients at risk for developing aspirin-associated gastric ulcers. This study is designed to
provide long-term safety data for PA32540 in order to gain regulatory approval to make
PA32540 available for clinical use in this subject population.

Inclusion criteria:

1. A. Male or non-pregnant, non-breastfeeding females who have been on daily aspirin 325
mg for at least three months and who are expected to use daily aspirin 325 mg for at
least six months (Daily is defined as "at least 5 days per week"):

AND, who are

- 55 years of age and older; or

- 18 - 54 years of age and have a history of a documented gastric or duodenal
ulcer within the past five years.

2. A. Aspirin use should be for the secondary prevention of cardiovascular or
cerebrovascular events as defined as follows:

Have been diagnosed with or have had a history of

- MI (myocardial infarction that has been confirmed or suspected)

- Ischemic stroke

- TIA (transient ischemic attack)

Or have established, clinically significant coronary and other atherosclerotic
vascular disease (meaning at high risk for surgical intervention or for MI, TIA,
stroke, if left untreated), including:

- Angina (stable or unstable)

- Peripheral arterial disease

- Atherosclerotic aortic disease

- Carotid artery disease Or have had

- CABG (coronary artery bypass graft)

- PCI (percutaneous coronary intervention with or without stent)

- Carotid endarterectomy

3. A. If female, subjects are eligible if they are of

1. non-childbearing potential (i.e., physiologically incapable of becoming
pregnant); or,

2. childbearing potential, have a negative pregnancy test at screening, and at
least one of the following applies or is agreed to by the subject:

- Female sterilization or sterilization of male partner

- Hormonal contraception by oral route, implant, injectable, vaginal ring

- Any intrauterine device (IUD) with published data showing that the lowest
expected failure rate is less than 1% per year

- Double barrier method (2 physical barriers or 1 physical barrier plus
spermicide)

- Any other method with published data showing that the lowest expected
failure rate is less than 1% per year 4. Able to understand and comply with
study procedures required and able and willing to provide written informed
consent prior to any study procedures being performed

Exclusion criteria:

1. Any current gastric, esophageal or duodenal ulcer

2. Positive test result for H. pylori at screening 3A. Have had a revascularization
procedure (i.e., Coronary Artery Bypass Graft, Percutaneous Transluminal Coronary
Angioplasty, or carotid endarterectomy) less than six months prior to screening

4. Unstable hypertension as judged by the Investigator 5. Uncontrolled diabetes mellitus
as judged by the Investigator 6. Unstable cardio- or cerebrovascular disease such that it
would endanger the subject if they participated in the trial 7. Clinically significant
valvular disease 8. Congestive heart failure or other cardiovascular symptoms according to
New York Heart Association (NYHA) Functional Classification III-IV (Appendix 3) 9. History
of hypersensitivity to omeprazole or to another proton pump inhibitor 10. History of
allergic reaction or intolerance to aspirin and/or a history of aspirin-induced symptoms
of asthma, rhinitis, and/or nasal polyps 11. History of serious UGI event, such as
bleeding, perforation, or obstruction 12. Gastrointestinal disorder or surgery leading to
impaired drug absorption 13. Presence of chronic or uncontrolled acute medical illness,
e.g. gastrointestinal disorder (esophageal stricture, severe esophagitis, long-segment
Barrett's esophagus, signs and symptoms of gastric outlet obstruction), thyroid disorder
and/or infection that would endanger a subject if they were to participate in the study
14. Schizophrenia, uncontrolled bipolar disorder, or severe depression 15. History of
alcoholism or drug addiction within a year prior to enrollment in the study 16. Severe
hepatic dysfunction (i.e. cirrhosis or portal hypertension) 17. Blood coagulation
disorder, including use of systemic anticoagulants such as warfarin or other vitamin K
antagonists 18. Any condition that, in the opinion of the Investigator, may either put the
subject at risk or influence the results of the study 19. Use of any excluded concomitant
medication (see Section 9.2) 20. Screening laboratory ALT or AST value > two times the
upper limit of normal 21A. History of renal insufficiency 22. Other than noted
specifically, any screening laboratory value that is clinically significant in the
Investigator's opinion and would endanger a subject if the subject was to participate in
the study 23. Use of an investigational treatment in the 4 weeks before screening 24.
History of malignancy, treated or untreated, within the past five years, with the
exception of successfully treated basal cell or squamous cell carcinoma of the skin 25.
Previous participation in another PA32540 clinical research study 26. Subjects, who are
employees of the research facility, immediately related to the Investigator, or are in
some way under the supervision of the Investigator.