Effect of 4-week Dihydrocapsiate Ingestion on Resting Metabolic Rate

This study is a double-blind, placebo-controlled, single center, randomized, parallel arm
clinical trial to test the impact of Dihydrocapsiate (placebo, 3 and 9 mg/d) ingested for 4
weeks on resting metabolic rate and fat oxidation measured by indirect calorimetry.

Inclusion Criteria:

- Men between 20-60 years old

- Healthy as assessed by medical history and standard medical exam

- Weight-stable

- Body mass index of 25 to 34.9 kg/m2

- Non-smoker

- Sedentary lifestyle: not being physically active grater than 3 days/week for 20 min
each time for the previous 6 months, and not participating in regular resistance
exercise.

Exclusion Criteria:

- Subjects enrolled in a diet to increase or decrease body weight

- Special diet or food aversiions to common foods

- Has allergy to chilli pepper

- Eating chilli peppers on a daily basis

- Usually consuming more than 2 cups of tea or coffee/day

- Usually consuming more than 4 cans of caffeinated soft drinks a day

- Usually consuming more than 3 standard alcohol drinks/day

- Regular use of medications (weight loss drugs, drugs affecting energy metabolism,
drugs for depression)

- Usual intake of illicit substances

- Claustrophobia

- Participating or having participated in another clinical trial during the last 4
weeks prior to the beginning of this study