The Migraine and Pain Study GeneBank at Scripps Clinic Registry (MAPS)

It is estimated that over one-third of the world's population suffers from persistent or
recurrent pain. Migraine is highly heritable and the majority of juveniles who suffer from
the disorder have a mother or father who also have the disease. The blood or saliva samples
will go through DNA analysis and be sequenced for candidate genes or subjected to
whole-genome sequencing. By creating a MAPS GeneBank from these patients' blood/saliva
donations we will ultimately be able to define genes for migraine and pain diseases.

Inclusion Criteria:

1. Family members (genetic duo or trio), consisting of an adolescent 10 to 18 years of
age and at least one of their biologic parents willing to be participate in trial

2. Adolescent and at least 1 biologic parent with Migraine diagnosis confirmed by Dr.
Christy Jackson

3. Is reliable, cooperative and willing to comply with all protocol-specified procedures
and/or sub-study if consented

4. Able to understand and grant informed consent

Exclusion Criteria:

1. Patient has been previously enrolled in the MAP GeneBank at Scripps Clinic Registry

2. Has a significant chronic medical condition (i.e.chronic meningitis or a secondary
origin/cause of headache) which, in the investigator's option, may interfere with the
patient's optimal participation in the study

3. Treatment with any investigational agents or devices within 30 days preceding
enrollment in the study

4. Has undergone ECT within 90 days preceding enrollment in the study