Evaluate a Medication on How Hunger and Appetite Are Influenced by Smell
| Status: | Terminated |
|---|---|
| Conditions: | Food Studies |
| Therapuetic Areas: | Pharmacology / Toxicology |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 4/21/2016 |
| Start Date: | October 2009 |
| End Date: | November 2009 |
A Single Dose Pilot Study to Evaluate the Safety and Dose-Response of Smell to Intranasal Diltiazem
The purpose of this study is to determine whether the blood pressure medication, diltiazem,
will temporarily decrease the sense of smell when given in a nasal spray which will then
reduce food intake.
will temporarily decrease the sense of smell when given in a nasal spray which will then
reduce food intake.
You will fast on your first visit. Complete questionnaire about taste and smell to insure
you don't have a cold or anything that would interfere with sense of smell. Your nose will
be checked. Blood pressure taken, and administer to you a spray with diltiazem 2, 4, 8 mg or
a placebo. Your sense of smell will be tested at different time points.
you don't have a cold or anything that would interfere with sense of smell. Your nose will
be checked. Blood pressure taken, and administer to you a spray with diltiazem 2, 4, 8 mg or
a placebo. Your sense of smell will be tested at different time points.
Inclusion Criteria:
- Body mass index (BMI) between 25 and 40 kg
- Blood pressure in within normal range
Exclusion Criteria:
- Used tobacco products in the past month
- Used a calcium channel blocker medication in the last month
- used nasal sprays in the last month
- have an abnormal sense of smell or abnormalities of the lining in your nose
- female and have irregular menstrual periods
- female and are nursing a baby or pregnant
- female and have had a partial hysterectomy (still have ovaries)
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